143328-19-2

Basic information

• Product Name: 1-(4-bromophenyl)cyclopentanecarbonitrile(SALTDATA: FREE)
• Synonyms: 1-(4-bromophenyl)cyclopentanecarbonitrile(SALTDATA: FREE);1-(4-Bromophenyl)cyclopentanecarbonitrile;4-(1-Cyanocyclopentyl)bromobenzene;CYCLOPENTANECARBONITRILE, 1-(4-BROMOPHENYL)-;1-(4-bromophenyl)cyclopentanecarbonitrile(SALTDATA
• CAS NO: 143328-19-2
• Molecular Formula: C₁₂H₁₂BrN
• Molecular Weight: 250.13
• Mol File: 143328-19-2.mol

Chemical Properties

• Boiling Point: 351.3°C at 760 mmHg
• Flash Point: 166.3°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 4.14E-05mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-bromophenyl)cyclopentanecarbonitrile(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)cyclopentanecarbonitrile(SALTDATA: FREE)(143328-19-2)
• EPA Substance Registry System: 1-(4-bromophenyl)cyclopentanecarbonitrile(SALTDATA: FREE)(143328-19-2)

Safety Data

• Hazardous Substances Data: 143328-19-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-bromophenyl)cyclopentanecarbonitrile (SALTDATA: FREE) is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs and medications, contributing to the advancement of healthcare and medical treatments.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 1-(4-bromophenyl)cyclopentanecarbonitrile (SALTDATA: FREE) serves as a valuable intermediate for the synthesis of a wide range of organic compounds. Its versatility in chemical reactions enables the creation of diverse molecules with potential applications in various industries.
Used in Research and Development:
1-(4-bromophenyl)cyclopentanecarbonitrile (SALTDATA: FREE) is utilized as a building block in the production of advanced materials and compounds for research and development purposes. Its unique properties and reactivity make it an essential component in the exploration of new chemical pathways and the discovery of innovative materials with potential applications in various fields.

InChI:InChI=1/C12H12BrN/c13-11-5-3-10(4-6-11)12(9-14)7-1-2-8-12/h3-6H,1-2,7-8H2

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 16532-79-9 4-Bromophenylacetonitrile 

Downstream Products

• 143328-24-9 1-(4-bromophenyl)cyclopentanecarboxylic acid 
• 1419174-47-2 C₂₁H₂₂O₂ 
• 1419174-60-9 1-(4'-isopropyl-[1,1'-biphenyl]-4-yl)cyclopentanecarboxylic acid 
• 1419174-73-4 C₂₁H₂₃N 
• 1267113-92-7 1-(4-bromophenyl)cyclopentane-1-carbaldehyde 
• 1346689-83-5 [1-(4-bromophenyl)cyclopentyl]methanol 
• 1616924-20-9 methanesulfonic acid 1-(4-bromophenyl)cyclopentylmethyl ester 
• 1616924-21-0 2-[1-(4-bromophenyl)cyclopentyl]acetonitrile 
• 1616922-09-8 4-[1-(9-hydroxy-2-isopropyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrazino[1,2-c]pyrimidin-6-ylmethyl)cyclopentyl]benzonitrile 
• 1616924-27-6 9-benzyloxy-6-[1-(4-bromophenyl)cyclopentylmethyl]-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 1616924-26-5 5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide 
• 1616924-25-4 5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide 
• 1616924-24-3 5-benzyloxy-2-[[1-(4-bromophenyl)cyclopentyl]methyl]-6-hydroxypyrimidine-4-carboxylic acid 
• 1616924-23-2 5-benzyloxy-2-[1-(4-bromophenyl)cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid tert-butyl ester 

Relevant articles and documents

Amide compound and derivative thereof, preparation method, pharmaceutical composition and application thereof

The invention discloses an amide compound and derivative thereof, a preparation method, a pharmaceutical composition and application thereof. The structure of the amide compound is shown as a formula (I). The derivatives of theamide compound relate to a stereoisomer, a tautomer, a metabolite, a metabolic precursor, a prodrug, a solvate, a salt of the solvate, a crystal, a pharmaceutically acceptable salt or a mixture of the above of theamide compound. The amide compound and the derivative thereof have an efficient inhibition effect on indoleamine 2, 3-dioxygenase 1, and can be used for preparing medicines for treating indoleamine 2, 3-dioxygenase 1 mediated immunosuppression related diseases, the prepared medicine can exert the medicine effect at the molecular level and is wide in application, and the synthesis method of the compound is simple, convenient and easy to operate.

CHEMOSELECTIVE METHYLENE HYDROXYLATION IN AROMATIC MOLECULES

A chemoselective and reactive Mn(CF3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic C—H hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.

Bioinspired Metal-Free Formal Decarbonylation of α-Branched Aliphatic Aldehydes at Ambient Temperature

A sequence of a Baeyer–Villiger oxidation and a Lewis acid-promoted reduction of the resulting formate with Et3SiH enabled the metal-free formal decarbonylation of tertiary and secondary aliphatic aldehydes. The new methodology mimics the biosynthetic decarbonylation pathway through oxidative C?C bond cleavage rather than the C(O)?H bond activation known from conventional Tsuji–Wilkinson-type reactions. The substrate scope is complementary to existing transition-metal-catalyzed protocols.

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

Direct lactonization of 2-arylacetic acids through Pd(II)-catalyzed C-H activation/C-O formation

Palladium-catalyzed direct lactonization of 2-arylacetic acids through a reaction sequence that includes C-H activation/C-O formation is reported. This method provides a concise and efficient pathway to synthesize fully functionalized benzofuranone derivatives, which are highly relevant to bioactive natural and synthetic products.

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.

Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans

This invention is directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans that inhibit Factor Xa, pharmaceutical compositions comprising these compounds and their use for inhibiting Factor Xa or treating pathological conditions in a patient that may be ameliorated by administration of such compounds. This invention is also is also directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans which directly inhibit both Factor Xa and Factor IIa (thrombin), to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of simultaneously directly inhibiting both Factor Xa and Factor IIa (thrombin).