143382-95-0

Basic information

• Product Name: 1-cyclopropyl-7-{(3R)-3-[(1R)-1-(ethylamino)ethyl]pyrrolidin-1-yl}-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• Synonyms: 1-Cyclopropyl-7-{(3R)-3-[(1R)-1-(ethylamino)ethyl]-1-pyrrolidinyl}-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 3-quinolinecarboxylic acid, 1-cyclopropyl-7-[(3R)-3-[(1R)-1-(ethylamino)ethyl]-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-
• CAS NO: 143382-95-0
• Molecular Formula: C₂₂H₂₈FN₃O₄
• Molecular Weight: 417.4738
• Mol File: 143382-95-0.mol

Chemical Properties

• Boiling Point: 608.8°C at 760 mmHg
• Flash Point: 322°C
• Density: 1.327g/cm³
• Vapor Pressure: 1.13E-15mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 1-cyclopropyl-7-{(3R)-3-[(1R)-1-(ethylamino)ethyl]pyrrolidin-1-yl}-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-7-{(3R)-3-[(1R)-1-(ethylamino)ethyl]pyrrolidin-1-yl}-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(143382-95-0)
• EPA Substance Registry System: 1-cyclopropyl-7-{(3R)-3-[(1R)-1-(ethylamino)ethyl]pyrrolidin-1-yl}-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(143382-95-0)

Safety Data

• Hazardous Substances Data: 143382-95-0(Hazardous Substances Data)

Usage

Chemical class

Fluoroquinolone antibiotic

Molecular structure

Contains a cyclopropyl group, a pyrrolidinyl group, an ethylamino group, and a carboxylic acid group

Function

Antibacterial drug

Treatment uses

Variety of bacterial infections, including respiratory, urinary tract, skin, and soft tissue infections

Bacterial susceptibility

Effective against susceptible strains of bacteria

Prescription requirement

Must be prescribed by a healthcare professional

Upstream product

• 143408-53-1 -N-ethyl-α-methyl-3-pyrrolidinemethanamine 
• 847233-56-1 1-cyclopropyl-1,4-dihydro-6,7-difluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid difluoroborate ester 
• 143408-54-2 -N-ethyl-α-methyl-3-pyrrolidinemethanamine 

Relevant articles and documents

Quinolone Antibacterials Containing the New 7- Side Chain: The Effects of the 1-Aminoethyl Moiety and Its Stereochemical Configurations on Potency and in Vivo Efficacy

A series of stereochemically pure 7--1,4-dihydro-4-oxoquinoline and 1,8-naphthyridine-3-carboxylic acids, with varied substituents at the 1-, 5-, and 8-positions, were synthesized to study the effects of the 7-3-(1-aminoe

Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group

Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.