143426-48-6

Basic information

• Product Name: Ethyl 4-(1,2,4-Triazol-1-yl)benzoate
• Synonyms: Ethyl 4-(1,2,4-Triazol-1-yl)benzoate;Ethyl 4-(1H-1,2,4-triazol-1-yl);Ethyl 4-(1H-1,2,4-triazol-1-yl)benzoate
• CAS NO: 143426-48-6
• Molecular Formula: C₁₁H₁₁N₃O₂
• Molecular Weight: 217.22
• Product Categories: Acids and Derivatives;Heterocycles
• Mol File: 143426-48-6.mol

Chemical Properties

• Boiling Point: 378.5°C at 760 mmHg
• Flash Point: 182.7°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 6.25E-06mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Ethyl 4-(1,2,4-Triazol-1-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-(1,2,4-Triazol-1-yl)benzoate(143426-48-6)
• EPA Substance Registry System: Ethyl 4-(1,2,4-Triazol-1-yl)benzoate(143426-48-6)

Safety Data

• Hazardous Substances Data: 143426-48-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Ethyl 4-(1,2,4-Triazol-1-yl)benzoate is used as a key intermediate in the synthesis of pharmaceutical drugs. Its unique chemical properties and reactivity contribute to the development of new therapeutic agents for the treatment of various diseases.
Used in Agrochemical Production:
Ethyl 4-(1,2,4-Triazol-1-yl)benzoate is also utilized in the production of agrochemicals, where it serves as an intermediate in the synthesis of compounds that help protect crops from pests and diseases, thereby enhancing agricultural productivity.
Used in Cancer Treatment:
Ethyl 4-(1,2,4-Triazol-1-yl)benzoate is used as a potential therapeutic agent in the treatment of cancer. Its biological activity and unique structure make it a promising candidate for the development of new cancer-fighting drugs.
Used in Antifungal Applications:
It is employed as an antifungal agent, leveraging its biological activity to combat fungal infections, which is crucial in both medical and agricultural settings.
Used in Antibacterial Applications:
Ethyl 4-(1,2,4-Triazol-1-yl)benzoate is also used in the development of antibacterial agents, contributing to the fight against bacterial infections that pose significant health and agricultural challenges.
Used in Chemical Intermediates:
In the chemical industry, Ethyl 4-(1,2,4-Triazol-1-yl)benzoate is used as an intermediate for the production of other chemicals and materials, highlighting its versatility and importance in various chemical processes.

InChI:InChI=1/C11H11N3O2/c1-2-16-11(15)9-3-5-10(6-4-9)14-8-12-7-13-14/h3-8H,2H2,1H3

Upstream product

• 288-88-0 1,2,4-Triazole 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 143426-50-0 [4-(1H-1,2,4-triazol-1-yl)phenyl]methanol 
• 58419-68-4 4-[1,2,4]Triazol-1-yl-benzoic acid hydrazide 
• 143426-53-3 1-(4-(chloromethyl)phenyl)-1H-1,2,4-triazole 
• 143426-56-6 4-(1H-1,2,4-triazol-1-yl)phenylacetonitrile 
• 143426-64-6 (4-[1,2,4]Triazol-1-yl-phenyl)-acetic acid 
• 143426-70-4 (E)-3-(4-[1,2,4]Triazol-1-yl-phenyl)-acrylic acid ethyl ester 
• 139311-95-8 (4-[1,2,4]Triazol-1-yl-phenyl)-acetic acid hydrazide 
• 143426-65-7 (4-[1,2,4]Triazol-1-yl-phenyl)-acetic acid ethyl ester 
• 143426-73-7 3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid ethyl ester 
• 139311-96-9 3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid hydrazide 
• 27996-86-7 4-(1H-1,2,4-triazol-1-yl)benzaldehyde 
• 162848-16-0 4-(1H-1,2,4-triazol-1-yl)-benzoic acid 

Relevant articles and documents

Sulfonamide derivatives, their production and use

The present invention provides compounds which specifically inhibit FXa, which are effective when orally administered and which are useful as a safe medicine for the prevention or treatment of diseases caused by thrombus or infarction. Compounds of this invention are piperazinones of the formula: wherein R1is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; the ring A is an optionally substituted divalent nitrogen-containing heterocyclic group, in addition to being substituted by the group of the formula: and the group of the formula: Y is an optionally substituted divalent hydrocarbon group or an optionally substituted divalent heterocyclic group; X is a direct bond or an optionally substituted alkylene chain; Z is (1) an amino group substituted with an optionally substituted hydrocarbon group, (2) an optionally substituted imino group or (3) an optionally substituted nitrogen-containing heterocyclic group; provided that when X is a direct bond and Z is an optionally substituted 6-membered nitrogen-containing aromatic heterocyclic group, Y is an optionally substituted divalent hydrocarbon group or an optionally substituted divalent unsaturated heterocyclic group; or a salt thereof.

Peripheral vasodilating agent containing piperidine derivative as active ingredient

The present invention relates to novel peripheral vasodilating agents characterized by each containing as an active ingredient, a piperidine derivative or pharmaceutically acceptable salt thereof having excellent peripheral vasodilating activity. Said pip

Aromatic hydrazides as specific inhibitors of bovine serum amine oxidase

New hydrazides were synthesized in search for specific inhibitors of bovine serum amine oxidase: a series of benzoic and phenylacetic acid hydrazides containing the 1H-imidazol-1-yl or the 1H-imidazol-1-ylmethyl group as (o,m,p)-substituent in the phenyl ring; an analogous series of p-substituted phenylhydrazides with 5 or 6-membered heterocyclic ring as substituent, and a series of similar phenylpropionic hydrazides. The longer and more flexible phenylacetic hydrazides, and to a somewhat lesser extent the phenylpropionic ones, were better specific inhibitors of bovine serum amine oxidase than the benzoic hydrazides, which were also bound by the enzyme with high affinity, but at a slow rate. Derivatives with p- and m-substituents were more reactive than the o-substituted ones. The chemical nature of the substituent was less important than its position in the phenyl ring and the presence of methylene spacers. These data point to the presence of a hydrophobic site at short distance from the protein carbonyl cofactor, so that simultaneous interaction of the 2 ends of the inhibitor molecule can occur at the 2 sites. The presence of the hydrophobic site was confirmed by the capability of some molecule deprived of the hydrazidic group to act as mild inhibitors. All hydrazides were less reactive by 2-3 orders of magnitude towards pig kidney diamine oxidase and FAD-dependent monoamine oxidase from rat brain mitochondria, while the other compounds showed similar inhibition power against all proteins. The specificity for the bovine enzyme seems therefore to be related to the concerted action of the 2 moieties of the inhibitor molecule.