143426-50-0

Basic information

• Product Name: [4-(1H-1,2,4-Triazol-1-yl)phenyl]methanol
• Synonyms: BUTTPARK 95\50-83;(4-[1,2,4]TRIAZOL-1-YL-PHENYL)METHANOL;[4-(1H-1,2,4-TRIAZOL-1-YL)PHENYL]METHANOL;RARECHEM AL BD 1325;1-[4-(Hydroxymethyl)phenyl]-1H-1,2,4-triazole;(4-[1,2,4]TRIAZOL-1-YL-PHENYL)METHANOL, 95+%;4-(1,2,4-Triazol-1-yl)benzyl Alcohol;1-[4-(Hydroxymethyl)phenyl]-1H-1,2,4-triazole, 4-(1H-1,2,4-Triazol-1-yl)benzyl alcohol
• CAS NO: 143426-50-0
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.19
• Product Categories: Alcohols and Derivatives;Heterocycles
• Mol File: 143426-50-0.mol

Chemical Properties

• Melting Point: 124-126°C
• Boiling Point: 383°Cat760mmHg
• Flash Point: 185.4°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 1.51E-06mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: 2-8°C
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: [4-(1H-1,2,4-Triazol-1-yl)phenyl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(1H-1,2,4-Triazol-1-yl)phenyl]methanol(143426-50-0)
• EPA Substance Registry System: [4-(1H-1,2,4-Triazol-1-yl)phenyl]methanol(143426-50-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 143426-50-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[4-(1H-1,2,4-Triazol-1-yl)phenyl]methanol is used as an intermediate in the synthesis of pharmaceuticals for its role in creating biologically active compounds. Its potential as an antifungal and antitumor agent makes it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, [4-(1H-1,2,4-Triazol-1-yl)phenyl]methanol is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective products for agricultural applications.
Used in Organic Synthesis:
[4-(1H-1,2,4-Triazol-1-yl)phenyl]methanol is used as a building block in organic synthesis, allowing for the preparation of a variety of compounds with potential applications in different fields.
Used in Medicinal Chemistry Research:
[4-(1H-1,2,4-Triazol-1-yl)phenyl]methanol is used in medicinal chemistry research as a key component in the preparation of biologically active molecules, aiding in the discovery and development of new therapeutic agents.
Used in Treatment of Certain Diseases:
[4-(1H-1,2,4-Triazol-1-yl)phenyl]methanol has been studied for its potential use in the treatment of certain diseases, showcasing its versatility as a building block for the preparation of diverse therapeutic agents.

InChI:InChI=1/C9H9N3O/c13-5-8-1-3-9(4-2-8)12-7-10-6-11-12/h1-4,6-7,13H,5H2

Upstream product

• 143426-48-6 ethyl 4-(1,2,4-triazol-1-yl)benzoate 
• 27996-86-7 4-(1H-1,2,4-triazol-1-yl)benzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 1187450-97-0 (6-((pyridin-3-ylsulfonyl)(4-(1,2,4-triazol-1-yl)benzyl)aminomethyl)pyridin-2-ylamino)acetic acid 
• 1187450-98-1 tert-butyl (tert-butoxycarbonyl(6-((pyridin-3-ylsulfonyl)(4-(1,2,4-triazol-1-yl)benzyl)aminomethyl)pyridin-2-yl)amino)acetate 
• 58419-67-3 methyl 4-(1,2,4-triazol-1-yl)benzoate 
• 25699-89-2 4-(1H-1,2,4-triazol-1-yl)benzonitrile 
• 139311-96-9 3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid hydrazide 
• 143426-73-7 3-(4-[1,2,4]Triazol-1-yl-phenyl)-propionic acid ethyl ester 
• 143426-65-7 (4-[1,2,4]Triazol-1-yl-phenyl)-acetic acid ethyl ester 
• 139311-95-8 (4-[1,2,4]Triazol-1-yl-phenyl)-acetic acid hydrazide 
• 143426-70-4 (E)-3-(4-[1,2,4]Triazol-1-yl-phenyl)-acrylic acid ethyl ester 
• 143426-64-6 (4-[1,2,4]Triazol-1-yl-phenyl)-acetic acid 
• 143426-56-6 4-(1H-1,2,4-triazol-1-yl)phenylacetonitrile 
• 27996-86-7 4-(1H-1,2,4-triazol-1-yl)benzaldehyde 
• 143426-53-3 1-(4-(chloromethyl)phenyl)-1H-1,2,4-triazole 

Relevant articles and documents

PYRROLIDINE GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, W, R3b, Z and p have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

Aromatic hydrazides as specific inhibitors of bovine serum amine oxidase

New hydrazides were synthesized in search for specific inhibitors of bovine serum amine oxidase: a series of benzoic and phenylacetic acid hydrazides containing the 1H-imidazol-1-yl or the 1H-imidazol-1-ylmethyl group as (o,m,p)-substituent in the phenyl ring; an analogous series of p-substituted phenylhydrazides with 5 or 6-membered heterocyclic ring as substituent, and a series of similar phenylpropionic hydrazides. The longer and more flexible phenylacetic hydrazides, and to a somewhat lesser extent the phenylpropionic ones, were better specific inhibitors of bovine serum amine oxidase than the benzoic hydrazides, which were also bound by the enzyme with high affinity, but at a slow rate. Derivatives with p- and m-substituents were more reactive than the o-substituted ones. The chemical nature of the substituent was less important than its position in the phenyl ring and the presence of methylene spacers. These data point to the presence of a hydrophobic site at short distance from the protein carbonyl cofactor, so that simultaneous interaction of the 2 ends of the inhibitor molecule can occur at the 2 sites. The presence of the hydrophobic site was confirmed by the capability of some molecule deprived of the hydrazidic group to act as mild inhibitors. All hydrazides were less reactive by 2-3 orders of magnitude towards pig kidney diamine oxidase and FAD-dependent monoamine oxidase from rat brain mitochondria, while the other compounds showed similar inhibition power against all proteins. The specificity for the bovine enzyme seems therefore to be related to the concerted action of the 2 moieties of the inhibitor molecule.