A new entry to carbocyclic nucleosides: Oxidative coupling reaction of cycloalkenylsilanes with a nucleobase mediated by hypervalent iodine reagent
(Chemical Equation Presented) A novel method for synthesizing carbocyclic nucleosides was developed. The new synthesis includes a direct coupling reaction of cycloalkenylsilanes with a silylated nucleobase catalyzed by a hypervalent iodine reagent. By app
Palladium-Catalyzed Rearrangements of 2-Cyclopentenyloxypyrimidines in the Preparation of Pyrimidine Carbonucleosides
Allylic 2-cyclopentenyloxypyrimidines have been prepared and rearranged by Pd(0)-induced catalysis to pyrimidine carbonucleosides analogues.For acid-sensitive substrates the rearrangement was performed in the presence of a base.Assignment of regio- and stereo-chemistry is based on NMR spectroscopy.