143584-75-2Relevant articles and documents
Functional activity of the mouse flavin-containing monooxygenase forms 1, 3, and 5
Zhang, Jun,Cerny, Matt A.,Lawson, Matt,Mosadeghi, Ruzbeh,Cashman, John R.
, p. 206 - 215 (2008/03/14)
Three functional mouse flavin-containing monooxygenases (mFMOs) (i.e., mFMO1, mFMO3, and mFMO5) have been reported to be the major FMOs present in mouse liver. To examine the biochemical features of these enzymes, recombinant enzymes were expressed as mal
Synthesis and antirheumatic activity of the metabolites of esonarimod
Noguchi, Toshiya,Onodera, Akira,Tomisawa, Kazuyuki,Yamashita, Miyuki,Takeshita, Kimiyo,Yokomori, Sadakazu
, p. 2713 - 2721 (2007/10/03)
We have developed esonarimod, (±)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid, as a new antirheumatic drug. Now we describe herein the preparation of the enantiomers of (±)-deacetylesonarimod, the pharmaceutically active metabolites of esonar
Microbial Oxidation of KE-298 Metabolites by Rhizopus sp. and Rhodococcus sp. Strains
Sasaki, Joji,Yoshida, Hideo,Tomisawa, Kazuyuki,Takeshita, Kimiyo,Adachi, Takashi
, p. 1048 - 1054 (2007/10/03)
The metabolites of the antirheumatic agent KE-298 in humans, (-)-(2R)-M-4 [(-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid], (-)-(2R)-M-5 [diastereomers of (-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylsulfinyl-methyl-4-oxobutanoic a