- Highly regioselective preparation of heteroaryl-magnesium reagents by using a Br/Mg exchange
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Disubstituted thienyl-, furyl- and pyridylmagnesium derivatives are regioselectively prepared from a Br/Mg exchange of the corresponding dibromo compounds by using either iPrMgCl·LiCl or hindered arylmagnesium reagents, such as isitylmagnesium bromide·lithium chloride (isityl=2,4,6-triisopropyl-phenyl) complexed with a diamine ligand, in difficult cases. The selective functionalisations of these heterocyclic scaffolds by using Negishi cross-coupling reactions, acylations or addition to aldehydes were readily achieved.
- S?mann, Christoph,Haag, Benjamin,Knochel, Paul
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supporting information
p. 16145 - 16152
(2013/02/21)
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