- DIRECT AMINATION OF 3(2H)-PYRIDAZINONES: RE-INVESTIGATION OF THE REACTION OF 3,6-DIMETHOXYPYRIDAZINE WITH HYDRAZINE
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3,6-Dimethoxypyridazine has been shown to react with hydrazine via 4-amination of 6- methoxy and 6-hydrazino-3(2H)-pyridazinones to give 4-amino-6-methoxy- and 4-amino-6-hydrazino-3(2H)-pyridazinones, and not the corresponding 5-amino isomers as previously reported.The published synthesis of the 5-amino isomers, used to confirm the earlier findings, is incorrect as regards 5-amino-6-hydrazino-3(2H)-pyridazinone, which has been prepared by an alternative route.The 4-aminnation reaction has been extended to 6-chloro-3(2H)-pyridazinone.
- Coates, William J.,McKillop, Alexander
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p. 1313 - 1329
(2007/10/02)
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