Stereocontrolled Route to the δ-Benzylidenemethyl-β-hydroxy-δ-lactone System Utilizing a New Chiral Epoxyacetylene Building Block
Stereocontrolled route to the δ-benzylidenemethyl-β-hydroxy-δ-lactone system has been developed utilizing a new epoxyacetylene building block prepared from optically active epichlorohydrin.The present synthesis allowed efficient construction of goniothalamin in natural and unnatural forms and its 3-hydroxy derivative having the essential anti-β/δ-stereochemistry for HMG Co-A reductase inhibition.