1437316-91-0

Basic information

• Product Name: 2,4-difluoro-3-iodoaniline
• Synonyms: 2,4-difluoro-3-iodoaniline
• CAS NO: 1437316-91-0
• Molecular Weight: 255.006
• Mol File: 1437316-91-0.mol

Chemical Properties

• Boiling Point: 266.7±40.0 °C(Predicted)
• Density: 2.086±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2,4-difluoro-3-iodoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-difluoro-3-iodoaniline(1437316-91-0)
• EPA Substance Registry System: 2,4-difluoro-3-iodoaniline(1437316-91-0)

Safety Data

• Hazardous Substances Data: 1437316-91-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-difluoro-3-iodoaniline is used as a synthetic intermediate for the preparation of purine derivatives. These derivatives act as protein kinase modulators, which are crucial in the treatment and prevention of protein kinase-mediated diseases. By targeting specific protein kinases, these modulators can help regulate cellular processes and potentially lead to therapeutic benefits for various conditions.

Upstream product

• 13697-89-7 2,6-difluoroiodobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 1145881-54-4 1,3-difluoro-2-iodo-4-nitrobenzene 

Downstream Products

• 1437316-92-1 N-(2,4-difluoro-3-(2-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenylamino)phenyl)propane-1-sulfonamide 
• 1392429-92-3 N-(2,4-difluoro-3-iodophenyl) propane-1-sulfonamide 
• 2183470-12-2 N-(3-((2-aminopyrimidin-5-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide 

Relevant articles and documents

HETEROCYCLIC COMPOUND

Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Protein kinase inhibitor and its composition and use thereof

The invention relates to compounds as shown in the general formula (I), pharmaceutical compositions containing the compounds, a method for treating diseases and disease symptoms related to abnormal activity of protein kinase by using the compounds, and medicinal use of the compounds.

KINASE MODULATING COMPOUNDS, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF

The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition.