143759-66-4Relevant articles and documents
Novel diphenylalkyl piperazine derivatives with dual calcium antagonistic and antioxidative activities
Kimura, Makoto,Masuda, Tomoko,Yamada, Koji,Kubota, Nobuo,Kawakatsu, Nobuyuki,Mitani, Masaki,Kishii, Kenichi,Inazu, Masato,Namiki, Takayuki
, p. 1947 - 1950 (2007/10/03)
Two types of novel diphenylalkyl piperazine derivatives containing the thio or aminopropanol moiety substituted by phenyl or benzyl group were synthesized, and evaluated for their calcium antagonistic and antioxidative activities. These compounds showed apparent inhibitions against KCl-induced contractions in isolated rat aorta. Among them, phenylamino compound 9 and benzylamino compound 13 also possessed potent inhibitory activities against auto-oxidative lipid peroxidations in canine brain homogenates. Two representative compounds 3a and 9 were evaluated for their inhibitory activities against KCl-induced contractions in isolated canine arteries (basilar, coronary, mesenteric, and renal). Both compounds showed the most potent inhibitions to basilar artery.
Diphenylpiperazine derivative and drug for circulatory organ containing the same
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, (2008/06/13)
A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: STR1 wherein R1 and R2 may be the same or different from each other a