- Preparation method of 2-chloro-4-amino-6-methylpyrimidine compound
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The invention discloses a preparation method of a 2-chloro-4-amino-6-methylpyrimidine compound. The preparation method comprises the steps that 2,4-dichloro-6-methylpyrimidine is used as a raw material, dimethylsulfoxide is used as a solvent, under the temperature of 40 DEG C to 45 DEG C, ammonia gas is introduced for substitution reaction, a required isomer product 2-chloro-4-amino-6-methylpyrimidine with high conversion is obtained, and then is treated into salt after acidification, and the pure final product 2-chloro-4-amino-6-methylpyrimidine compound is obtained by dissociating. Accordingto the preparation method, a purification and separation process which is more conductive to factory scale-up production is provided, the method is easy to operate, the post-treatment operation is simple, column chromatography is not required, salifying and dissociating are only required to purify the product, thus the part-level scale-up production of the product can be effectively achieved, theshortcomings of two routes in an existing technical literature are effectively overcome, and thus the disclosed preparation method has great economic value for lowering the cost.
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Paragraph 0012; 0013
(2020/03/06)
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- POLYCYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
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The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
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Paragraph 00390
(2019/07/19)
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- Pyri(mi)dyl-oxy-and -thio-benzoic acid derivatives useful as herbicides and plant growth regulants
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New pyri(mi)dyl-oxy- or -thio-benzoic acid derivatives of the formula STR1 are taught which have herbicidal and plant growth regulating activity. In the formula Z can be Ch or N, X is oxygen or sulphur, A is oxygen, sulphur, a radical R5 --N=or a radical R6 O--N=and B is oxygen, sulphur, a radical STR2 with the proviso that at least one of the radicals R1, R2 or R3 represents alkyl or a part of a 3- to 6-membered fused carbocyclic ring.
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