143982-40-5

Basic information

• Product Name: Imidazo[1,2-a]pyrimidine-2-carboxaldehyde (9CI)
• Synonyms: Imidazo[1,2-a]pyrimidine-2-carboxaldehyde (9CI);IMidazo[1,2-a]pyriMidine-2-carbaldehyde;Imidazo[1,2-a]pyrimidine-2-carboxaldehyde
• CAS NO: 143982-40-5
• Molecular Formula: C₇H₅N₃O
• Molecular Weight: 147.1341
• EINECS: 1308068-626-2
• Product Categories: ALDEHYDE
• Mol File: 143982-40-5.mol

Chemical Properties

• Melting Point: 209-211℃
• Appearance: /
• Density: 1.393 g/cm³
• PKA: 2.05±0.30(Predicted)
• CAS DataBase Reference: Imidazo[1,2-a]pyrimidine-2-carboxaldehyde (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyrimidine-2-carboxaldehyde (9CI)(143982-40-5)
• EPA Substance Registry System: Imidazo[1,2-a]pyrimidine-2-carboxaldehyde (9CI)(143982-40-5)

Safety Data

• Hazardous Substances Data: 143982-40-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Imidazo[1,2-a]pyrimidine-2-carboxaldehyde (9CI) is used as a building block for the synthesis of pharmaceutical drugs. Its unique structure and pharmacological properties make it a valuable component in the development of new medications with therapeutic potential.
Used in Organic Synthesis:
In the field of organic synthesis, Imidazo[1,2-a]pyrimidine-2-carboxaldehyde (9CI) serves as a starting material for the creation of new chemical entities. Its versatile properties allow for the exploration of novel compounds with potential applications in various areas of chemistry and medicine.
Used in Drug Discovery:
Imidazo[1,2-a]pyrimidine-2-carboxaldehyde (9CI) is utilized in drug discovery processes to identify and develop new therapeutic agents. Its anti-inflammatory, antifungal, and antitumor properties make it a promising candidate for the treatment of various diseases and conditions.

Upstream product

• 143982-38-1 2-(dichloromethyl)imidazo[1,2-a]pyrimidine 
• 57892-71-4 2-chloromethylimidazo<1,2-a>pyrimidine 
• 79-46-9 2-nitropropane 

Downstream Products

• 103-89-9 4-Methylacetanilide 

Relevant articles and documents

Toward the Synthesis of Sceptrin and Benzosceptrin: Solvent Effect in Stereo- and Regioselective [2+2] Photodimerization and Easy Access to the Fully Substituted Benzobutane

By simply switching solvents, two sets of conditions for the total regio- and stereoselective photodimerization of (E)-3-(imidazo[1,2-a]pyrimidin-2-yl)acrylic acid [(E)-7a] have been found. In acetonitrile in the presence of benzophenone as photosensitizer or in cyclohexane, the head-to-head cis-trans-cis isomer 8a was the only observable cycloadduct. In DMSO, the head-to-head trans-trans-trans isomer 10a was obtained as the unique cycloadduct. The diester 9a, derived from 8a, was cyclized to the challenging, fully substituted diimidazobenzobutane system 13 present in benzosceptrins.

Synthesis and antibacterial activity of novel imidazo [1,2-A] Pyrimidin- 2-Yl) methylene) benzohydrazides

The present paper reports the synthesis and antibacterial activity of new imidazo [1, 2-a] pyrimidin-2-yl) methylene) benzohydrazides 5a-j from commercially available 2-aminopyrimidine as starting material. The imidazo [1, 2-a] pyrimidin-2-yl) methylene)

Synthese et Reactions SRN1 en Serie 3-Nitroimidazopyrimidine

A new heterocyclic reductive alkylating agent, 2-chloromethyl-3-nitroimidazopyrimidine, is synthesized for the first time and shown to react under phase-transfer catalysis conditions with 2-nitropropane anion to give good yield of the C-alkylated derivative.Elimination of nitrous acid allows to obtain a new class of imidazopyrimidine derivatives bearing a trisubstituted ethylenic bond in the 2 position.The SRN1 mechanism of C-alkylation is confirmed by classical inhibition experiments by dioxygen, p-dinitrobenzene or TEMPO.