Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: Development of chemical probe ML315
Substituted pyrimidine inhibitors of the Clk and Dyrk kinases have been developed, exploring structure-activity relationships around four different chemotypes. The most potent compounds have low-nanomolar inhibitory activity against Clk1, Clk2, Clk4, Dyrk
Coombs, Thomas C.,Tanega, Cordelle,Shen, Min,Wang, Jenna L.,Auld, Douglas S.,Gerritz, Samuel W.,Schoenen, Frank J.,Thomas, Craig J.,Aubé, Jeffrey
p. 3654 - 3661
(2013/07/05)
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