144035-34-7

Basic information

• Product Name: [2-(5-Cyano-1H-indol-3-yl)-ethyl]-carbaMic acid tert-butyl ester
• Synonyms: [2-(5-Cyano-1H-indol-3-yl)-ethyl]-carbaMic acid tert-butyl ester;tert-Butyl (2-(5-cyano-1H-indol-3-yl)ethyl)carbamate
• CAS NO: 144035-34-7
• Molecular Formula: C16H19N3O2
• Molecular Weight: 285.34096
• Mol File: 144035-34-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: [2-(5-Cyano-1H-indol-3-yl)-ethyl]-carbaMic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(5-Cyano-1H-indol-3-yl)-ethyl]-carbaMic acid tert-butyl ester(144035-34-7)
• EPA Substance Registry System: [2-(5-Cyano-1H-indol-3-yl)-ethyl]-carbaMic acid tert-butyl ester(144035-34-7)

Safety Data

• Hazardous Substances Data: 144035-34-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[2-(5-Cyano-1H-indol-3-yl)-ethyl]-carbaMic acid tert-butyl ester is used as an intermediate in the synthesis of 5-Carboxamidotryptamine maleate (C338945) for its agonistic effects on the 5-HT1 receptors. [2-(5-Cyano-1H-indol-3-yl)-ethyl]-carbaMic acid tert-butyl ester plays a crucial role in the development of new drugs targeting the serotonin system, which is involved in various physiological processes and disorders, such as mood regulation, anxiety, and depression.
Used in Chemical Synthesis:
In the field of chemical synthesis, [2-(5-Cyano-1H-indol-3-yl)-ethyl]-carbaMic acid tert-butyl ester can be utilized as a building block or a key intermediate for the creation of more complex molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science. Its unique structural features make it a valuable component in the design and synthesis of novel compounds with specific biological activities or material properties.

Upstream product

• 467451-72-5 3-(2-nitroethyl)-1H-indole-5-carbonitrile 
• 467451-64-5 3-(2-nitrovinyl)-5-cyano-1H-indole 
• 17380-18-6 3-formyl-1H-indole-5-carbonitrile 
• 15861-24-2 1H-indole-5-carbonitrile 
• 873-74-5 4-Aminobenzonitrile 
• 2863-98-1 4-hydrazinobenzonitrile hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 101831-71-4 3-(2-aminoethyl)-5-cyano-1H-indole hydrochloride 
• 46276-24-8 3-(2-aminoethyl)-1H-indole-5-carbonitrile 

Relevant articles and documents

Methiodide Approach to the Synthesis of 3--5--1H-indole and Analogues

Tryptamines 1, 2 and 3 have been synthesised in a convergent and efficient manner by reaction of a novel methiodide 4c with the anions of the cyclic sulphamides 5, 6 and 7 as the key step.

N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR

The present invention relates to the use compounds of formula I which are antagonists of the 5-HT 6 receptor, for treating a cognitive disorder selected from the group consisting of age-related cognitive decline, mild cognitive impairment and dementia

Fused imidazole and triazole derivatives as 5-HT1 receptor agonists

Compounds of formula (I) wherein F represents a Group of the formula (a) ; E represents a bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; and the rest of the variables are defined in the specification are selective agoni

Synthesis and Biological Activity of 3--5--1H-indole and Analogues: Agonists for the 5-HT1D Receptor

A novel series of 5-(1,1-dioxo-1,2,5-thiadiazolidin-2-yl)tryptamines was designed, synthesized, and evaluated as 5-HT1D receptor agonists.Compounds such as 8d,f,k were identified which had comparable affinity, potency, and receptor selectivity

Triazole containing indole derivatives

A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.