- Rapid one-pot synthesis of alkane-α ω, diylbisphosphonic acids from dihalogenoalkanes under microwave irradiation
-
A one-pot, two-step synthesis of alkylenebisphosphonic acids from dihalogenoalkanes was performed under microwave irradiation. The reaction is very rapid and convenient for the synthesis of small samples of alkylenebisphosphonic acids. Copyright Taylor & Francis Group, LLC.
- Villemin, Didier,Moreau, Bernard,Kaid, M'Hamed,Didi, Mohamed Amine
-
-
Read Online
- PH-dependent syntheses, luminescence and magnetic properties of two-dimensional framework lanthanide 1,3-diarylphosphonate complexes
-
A series of novel organic-inorganic complexes based on trivalent lanthanides and 1,3-C6H4[CH2P(O)(OH) 2]2 (H4L) formulated as Ln(HL)(H 2O)2 (Ln = La, 1; Pr, 2; Nd, 3;
- Liu, Yi-Fu,Hou, Guang-Feng,Yu, Ying-Hui,Yan, Peng-Fei,Li, Guang-Ming,Gao, Jin-Sheng
-
-
Read Online
- The synthesis of novel bisphosphonates as inhibitors of phosphoglycerate kinase (3-PGK)
-
A series of conformationally-restrained analogues of 1,3-bisphospho-D-glyceric acid (1,3-BPG) 1 has been synthesised for use as inhibitors of 3-PGK (E.C. 2.7.2.3). These compounds have non-scissile phosphonate linkages and also incorporate α-halogen substituents to make them isopolar and isosteric mimics of the natural substrate. A monocyclic aryl core between the two phosphoryl centres provides both a rigid framework linking these moieties and loci for further substitution. The compounds were tested against human 3-PGK and found to be good competitive inhibitors. α-Fluorination of the phosphonic acids increased the affinity for the enzyme into the submicromolar range. Correlation of IC50 data with pKa. and pKa, values indicates that the acidity of the phosphoryl group exerts a strong influence on protein binding. The Royal Society of Chemistry 2000.
- Caplan, Neil A.,Pogson, Christopher I.,Hayes, David J.,Blackburn, G. Michael
-
p. 421 - 437
(2007/10/03)
-
- Phosphonic acid derivatives useful as anti-inflammatory agents
-
Novel acids, esters, and salts of phenyl, naphthyl, quinoxalinyl, and biphenyl bisphosphonic acids and 1,2-oxaphosphepins are described. These compounds are useful as antiinflammatory and anti-arthritic agents. Also described are known compounds of the phenyl, naphthyl, quinoxalinyl, and biphenyl bisphosphonate classes which are also useful as antiinflammatory and anti-arthritic agents. Representative compounds include [1,2-phenyldiyl]bis (methylene)bisphosphonic acid tetramethyl ester, [2,3-quinoxalindiyl]bis(methylene)bisphosphonic acid tetramethyl ester, [[3-(propyl)-4-(methoxy)-1,8-naphthalenediyl]bis(methylene)]bisphosphonic acid tetramethyl ester, [2,6-naphthalenediylbis(methylene) bisphosphonic acid tetraethyl ester, and [2,2'-biphenylenebis(methyl)]bisphosphonic acid tetramethyl ester. Representative oxaphosphepins include the preferred 3,4-dihydro-3-methoxy -7-(phenylmethoxy)-1H-naphth[1,8de][1,2]oxaphosphepin-3-oxide.
- -
-
-
- (o-Hydroxyphenyl)methylphosphonic acids: Synthesis and Potentiometric Determinations of their pKa Values
-
(o-Hydroxyphenyl)methylphosphonic acids are readily obtained from o-(bromomethyl)- or o-(hydroxymethyl)phenols and trialkyl phosphites.Subsequent hydrolysis leads to the corresponding phosphonic acids.For a series of such compounds, the pKa val
- Boehmer, Volker,Vogt, Walter,Chafaa, Salah,Meullemeestre, Jean,Schwing, Marie-Jose,Vierling, Francois
-
p. 139 - 149
(2007/10/02)
-