144060-98-0

Basic information

• Product Name: 4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid
• Synonyms: 4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid;4-Methyl-2-pyridin-4-yl-1,3-thiazole-5-carboxylic acid;4-Methyl-2-pyridin-4-yl-1,3-thiazole-5-carboxylic acid 95%;2-(4-Pyridyl)-4-methylthiazole-5-carboxylic acid;5-Thiazolecarboxylic acid, 4-Methyl-2-(4-pyridinyl)-;4-Methyl-2-(4-pyridinyl)-5-thiazolecarboxylic acid;2-(4-Pyridyl)-4-methylthiazole-5-carboxylic acid 97%;4-methyl-2-(4-pyridyl)-5-thiazolecarboxylic acid
• CAS NO: 144060-98-0
• Molecular Formula: C₁₀H₈N₂O₂S
• Molecular Weight: 220.24772
• Product Categories: C9 to C46Chemical Synthesis;Heterocyclic Building Blocks;Heterocyclic Building BlocksBuilding Blocks;New Products for Chemical Synthesis;Pyridines;Thiazoles
• Mol File: 144060-98-0.mol

Chemical Properties

• Melting Point: 254.5 °C
• Boiling Point: 467℃
• Flash Point: 236℃
• Appearance: /
• Density: 1.381
• Vapor Pressure: 1.6E-09mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: 2-8°C
• PKA: 1.71±0.37(Predicted)
• CAS DataBase Reference: 4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid(144060-98-0)
• EPA Substance Registry System: 4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid(144060-98-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36-36/37/38-22
• Safety Statements: 26-36/37/39-22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 144060-98-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid serves as an essential intermediate in the synthesis of drugs, leveraging its potential pharmacological activity for the development of new therapeutic agents. Its presence in drug molecules is attributed to its ability to modulate biological targets, making it a promising candidate for treating various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid is employed as a component in the creation of pesticides and other crop protection agents. Its incorporation enhances the effectiveness of these products, contributing to improved agricultural yields and pest control.
Used in Medicinal Chemistry Research:
4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid is utilized as a subject of study in medicinal chemistry, where its structure and functional groups are investigated for potential applications in anti-inflammatory, antimicrobial, and anticancer drug development. The exploration of its properties is crucial for identifying new avenues for therapeutic intervention.
Used in Drug Development:
As a part of the drug development process, 4-methyl-2-pyrid-4-yl-1,3-thiazole-5-carboxylic acid is examined for its potential to be incorporated into novel drug molecules. Its unique attributes make it a valuable asset in the design and synthesis of compounds aimed at addressing specific medical needs, including the treatment of inflammation, infections, and cancer.

InChI:InChI=1/C10H8N2O2S/c1-6-8(10(13)14)15-9(12-6)7-2-4-11-5-3-7/h2-5H,1H3,(H,13,14)

Upstream product

• 89401-54-7 ethyl 4-methyl-2-(4'-pyridinyl)-thiazole-5-carboxylate 
• 2196-13-6 pyridine-4-carbothioamide 

Downstream Products

• 1083418-92-1 4-methyl-2-pyridin-4-yl-thiazole-5-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 

Relevant articles and documents

Synthesis and characterizations of novel thiazolyl-thiadiazole derivatives as telomerase activators

Pyridine-3/4-thiocarboxamide derivatives were used as starting materials for the synthesis of the target compounds. The pyridine-3/4-thiocarboxamide derivatives were reacted with ethyl 2-chloroacetoacetate in ethanol to give the thiazole derivatives (1, 2). The two ethyl thiazole-carboxylate derivatives (1, 2) thus obtained were treated with sodium hydroxide solution and ethanol and converted to carboxylic acids (3, 4). The carboxylic acid derivatives (3, 4) were reacted with thiosemicarbazide in phosphoroxy trichloride and aminothiadiazole rings (5, 6) were formed. Thus, two thiazolyl-thiadiazole amine derivatives (5, 6) were obtained. These two derivatives (5, 6) were converted into two chloroacetamidothiadiazole derivatives (7, 8) by reaction with chloroacetylchloride over the amino group in the presence of triethylamine in acetone. After all these steps, the starting materials (7, 8) needed to reach the target compounds were obtained. With the two derivatives (7, 8) obtained in this last step, phenol and thiophenol derivatives were reacted in acetone in the presence of potassium carbonate. The target compounds, thiazolyl-thiadiazole derivatives (TDA1?16), are completely unique and their structure has been elucidated by elemental analysis, IR, NMR, and MS spectral data. After all these synthesis steps, telomerase activity studies were performed on the target compounds obtained. For this purpose, a PCR ELISA-based TRAP method was used on the heart of zebrafish. According to the enzyme assay results, derivative TDA8 has shown an increase of telomerase enzyme activity.

Identification, synthesis and photo-protection evaluation of arylthiazole derivatives as a novel series of sunscreens

A novel series of arylthiazole derivatives have been designed, synthesized and evaluated in preventing keratinocytes cell (HaCaT) from UVB exposure induced cellar damage. The structure-activity relationship (SAR) was discussed. More importantly, compound 5a significantly protected the dorsal skin of BALB/c-nu mice against UVB-induced decrustation in vivo. The in vitro and in vivo data for these arylthiazole derivatives suggest further studies for their potential use as photo-protection agents as well as sunscreen candidates.

Sulfonamide derivatives, their production and use

The present invention provides compounds which specifically inhibit FXa, which are effective when orally administered and which are useful as a safe medicine for the prevention or treatment of diseases caused by thrombus or infarction. Compounds of this invention are piperazinones of the formula: wherein R1is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; the ring A is an optionally substituted divalent nitrogen-containing heterocyclic group, in addition to being substituted by the group of the formula: and the group of the formula: Y is an optionally substituted divalent hydrocarbon group or an optionally substituted divalent heterocyclic group; X is a direct bond or an optionally substituted alkylene chain; Z is (1) an amino group substituted with an optionally substituted hydrocarbon group, (2) an optionally substituted imino group or (3) an optionally substituted nitrogen-containing heterocyclic group; provided that when X is a direct bond and Z is an optionally substituted 6-membered nitrogen-containing aromatic heterocyclic group, Y is an optionally substituted divalent hydrocarbon group or an optionally substituted divalent unsaturated heterocyclic group; or a salt thereof.