A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases
Lymphoid-specific tyrosine phosphatase (LYP), a member of the protein tyrosine phosphatase (PTP) family of signaling enzymes, is associated with a broad spectrum of autoimmune diseases. Herein we describe our structure-based lead optimization efforts with
He, Yantao,Liu, Sijiu,Menon, Ambili,Stanford, Stephanie,Oppong, Emmanuel,Gunawan, Andrea M.,Wu, Li,Wu, Dennis J.,Barrios, Amy M.,Bottini, Nunzio,Cato, Andrew C. B.,Zhang, Zhong-Yin
p. 4990 - 5008
(2013/07/26)
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