144167-50-0

Basic information

• Product Name: 5-BROMO-1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 5-BROMO-1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER;ethyl 5-bromo-1H-benzimidazole-2-carboxylate;Ethyl 5-broMo-1H-benzo[d]iMidazole-2-carboxylate;1H-Benzimidazole-2-carboxylic acid,6-bromo-,ethyl ester;5-bromo-1H-benzo[d]imidazole-2-carboxylate;6-Bromo-1H-benzoimidazole-2-carboxylic acid ethyl ester;ethyl 5-bromobenzimidazole-2-carboxylate
• CAS NO: 144167-50-0
• Molecular Formula: C10H9BrN2O2
• Molecular Weight: 269.09
• Mol File: 144167-50-0.mol

Chemical Properties

• Boiling Point: 403.351 °C at 760 mmHg
• Flash Point: 197.74 °C
• Appearance: /
• Density: 1.624 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 5-BROMO-1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(144167-50-0)
• EPA Substance Registry System: 5-BROMO-1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(144167-50-0)

Safety Data

• Hazardous Substances Data: 144167-50-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
5-BROMO-1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, leveraging its versatile reactivity and structural properties to create a wide range of bioactive compounds.
Used in Coordination Chemistry:
In the field of coordination chemistry, 5-BROMO-1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER is used as a ligand, forming complexes with various metal ions to explore new chemical and physical properties, as well as potential applications in catalysis, sensing, and materials science.
Used in Oncology Research and Therapeutics:
5-BROMO-1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER is used as a potential therapeutic agent in oncology, where it may contribute to the development of new treatments for various types of cancer. Its specific role in this field is still under investigation, but its structural features make it a promising candidate for further research and development.
Used in Medicinal Chemistry and Chemical Research:
5-BROMO-1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER is utilized in medicinal chemistry and chemical research for the exploration of its chemical properties, reactivity, and potential applications in drug discovery and development. Its unique structure and reactivity make it an important compound for advancing scientific understanding and creating innovative solutions in these fields.

InChI:InChI=1/C10H9BrN2O2/c1-2-15-10(14)9-12-7-4-3-6(11)5-8(7)13-9/h3-5H,2H2,1H3,(H,12,13)

Upstream product

• 1575-37-7 4-Bromo-benzene-1,2-diamine 
• 936939-48-9 5-bromo-2-(trichloromethyl)-1H-benzo[d]imidazole 
• 64-17-5 ethanol 
• 144167-28-2 α-amino-α-carbethoxy-N-(4-bromophenyl)-nitrone 
• 10468-46-9 N-(4-bromophenyl)hydroxylamine 
• 144167-45-3 2-(4-bromophenyl)-3-carbethoxy-Δ³-1,2,4-oxadiazolin-5-one 

Relevant articles and documents

INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF

Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions.

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula (I) wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with ex

Reactions of hydroxylamines with ethyl cyanoformate. Preparation of aminonitrones and their synthetic applications

The reaction of hydroxylamines with ethyl cyanoformate 1 leads to the formation of carbethoxyamino nitrones. 2. UV spectroscopy provided information that suggested the nitrone structure for these compounds in solution. X-ray analysis of 2a confirmed that it exists entirely in the nitrone form in the solid state. These nitrones are shown to be excellent starting materials for a variety of nitrogen containing compounds, namely, imidazoles, benzimidazoles, benzimidazolones, oxadiazolones, N-arylamidines and quinoxalone.