144288-48-2

Basic information

• Product Name: 3-Pyridinemethanamine,2-amino-(9CI)
• Synonyms: 3-Pyridinemethanamine,2-amino-(9CI);3-(aminomethyl)-2-pyridinamine(SALTDATA: FREE)
• CAS NO: 144288-48-2
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.15576
• Product Categories: PYRIDINE
• Mol File: 144288-48-2.mol

Chemical Properties

• Boiling Point: 293.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.173±0.06 g/cm3(Predicted)
• PKA: 8.13±0.29(Predicted)
• CAS DataBase Reference: 3-Pyridinemethanamine,2-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinemethanamine,2-amino-(9CI)(144288-48-2)
• EPA Substance Registry System: 3-Pyridinemethanamine,2-amino-(9CI)(144288-48-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 144288-48-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyridinemethanamine,2-amino-(9CI) is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs. Its presence in the molecular structure of certain compounds can enhance their therapeutic properties, making it a valuable component in drug discovery and design.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Pyridinemethanamine,2-amino-(9CI) is used as a building block in the creation of pesticides and herbicides. Its incorporation into these compounds can improve their effectiveness in controlling pests and unwanted plant growth, thereby contributing to increased crop yields and agricultural productivity.
Used in Organic Synthesis:
3-Pyridinemethanamine,2-amino-(9CI) is utilized as a key component in the preparation of other organic compounds, serving as a versatile building block in chemical reactions. Its reactivity and structural properties make it suitable for a wide range of applications in organic chemistry, from the synthesis of complex molecules to the modification of existing ones.
Overall, 3-Pyridinemethanamine,2-amino-(9CI) is a multifaceted chemical compound with diverse applications in various industries, particularly in the development and production of pharmaceuticals and agrochemicals, as well as in organic synthesis for the creation of new materials and substances.

Upstream product

• 13438-65-8 2-aminopyridine-3-carboxamide 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 24517-64-4 2-amino-3-pyridinecarbonitrile 

Downstream Products

• 144288-40-4 2-(2,3-Dichloro-phenoxymethyl)-1,4-dihydro-pyrido[2,3-d]pyrimidine 
• 1057650-80-2 tert-butyl [(2-aminopyridin-3-yl)methyl]carbamate 

Relevant articles and documents

Pyridine methylamine compound and preparation method thereof

The invention provides a pyridine methylamine compound and a preparation method thereof. The preparation method comprises the steps that tetrahydrofuran and sodium borohydride are sequentially added into a cyanopyridine compound, then an iodine-containing tetrahydrofuran solution is dropwise added, a reaction is conducted at the temperature of 20-30 DEG C, and after dropwise adding is completed, stirring is carried out continuously; after the reaction is finished, methanol is added for refluxing, extracting and spin-drying are carried out to obtain the pyridine methylamine compound; wherein a functional group in the cyanopyridine compound is selected from chlorine, bromine, methyl, ethyl, amino or hydrogen; according to the preparation method, high-temperature and high-pressure special equipment does not need to be used, so that the preparation method is relatively safe, and dangerous accidents such as explosion and fire disasters are avoided; besides, the preparation method is relatively environment-friendly, recycling treatment of hazardous waste (used Raney nickel) is not involved, the economic benefit is relatively high, borane generated by the synthesis method is converted into boric acid esters in the post-treatment process, the treatment cost is low, and the harm to the environment is much small.

α2-adrenoceptor antagonists: Synthesis, pharmacological evaluation, and molecular modeling investigation of pyridinoguanidine, pyridino-2-aminoimidazoline and their derivatives

We have previously identified phenylguanidine and phenyl-2-aminoimidazoline compounds as high affinity ligands with conflicting functional activity at the α2-adrenoceptor, a G-protein-coupled receptor with relevance in several neuropsychiatric conditions. In this paper we describe the design, synthesis, and pharmacological evaluation of a new series of pyridine derivatives [para substituted 2- and 3-guanidino and 2- and 3-(2-aminoimidazolino)pyridines, disubstituted 2-guanidinopyridines and N-substituted-2-amino-1,4-dihydroquinazolines] that were found to be antagonists/inverse agonists of the α2-adrenoceptor. Furthermore, the compounds exert their effects at the α2-adrenoceptor both in vitro in human prefrontal cortex tissue and in vivo in rat brain as shown by microdialysis experiments. We also provide a docking study at the α2A- and α2C-adrenoceptor subtypes demonstrating the structural features required for high affinity binding to the receptor.

2-Aminomethylphenylamine as a novel scaffold for factor Xa inhibitor

We have been researching orally active factor Xa inhibitor for a long time. We explored the new diamine linker using effective ligands to obtain a new attractive original scaffold 2-aminomethylphenylamine derivative. Compound 1D showed very strong in vitro and in vivo factor Xa inhibitory activity, as well as favorable PK profiles in po administration to monkeys.

PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN

Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows: wherein A1, L1, D, and Q are defined herein.

Prokineticin 1 receptor antagonists

The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.

PROKINETICIN 2 RECEPTOR ANTAGONISTS

The present invention relates to certain novel compounds of Formula (I): and methods for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.