- QUINOLIN-2-ONE DERIVATIVES
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Compounds of the formula (I) in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
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Page/Page column 81
(2017/08/07)
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- A practical route to C-8 substituted fluoroquinolones
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The ortho metalation of N-(tert-butoxycarbonyl)-3,4-difluoroaniline, with t-BuLi at -78°C in THF occurred regioselectively at C-2 position. The resulting lithiated species reacted with a variety of electrophiles to give 2-substituted-3,4-difluoranilines i
- Carretero,Garcia Ruano,Vicioso
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p. 7373 - 7382
(2007/10/02)
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