- Design and synthesis of new series of 3-cyanopyridine and pyrazolopyridine derivatives
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Reaction of 3-cyano-4,6-dimethyl-2-pyridone with ethyl chloroacetate afforded ethyl 2-([3-cyano-4,6-dimethylpyridin-2-yl]oxy)acetate 2 and ethyl 2-(3-cyano-4,6-dimethyl-2-oxopyridin-1[2H]-yl)acetate 3, the reaction product yield depend on the reaction condition (potassium carbonate concentration and reaction time). These compounds used as precursors to synthesize pyridine derivatives 4, 6-10, 15, 17-20, furopyridines 5, 16, pyrazolopyridine 12, pyridopyrazolopyrimidines 14a,b. The structure of the newly synthesized compounds was confirmed by spectral data (IR, NMR, and mass spectra) and elemental analysis.
- Keshk, Reda Mohammed
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