- Synthesis and Anticancer Activity of Some New 4-Azaindoleisoxazoles
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Abstract: Herein, synthesis of new 4-azaindole-1,2,4-isoxazoles by Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction of [4-(prop-2-yn-1-yl)piperazin-1-yl](1H-pyrrolo[3,2-b]pyridin-3-yl)methanone with several aromatic aldehydes is presented. All products have been tested for their in vitro anticancer activity against three human cancer cell lines including A549 (lung), A375 (melanoma) and MCF7 (breast). The results of the tests indicate that two products are highly active against all cell lines with the activity superior to that of the standard doxorubicin. Also two products demonstrate inhibitory activity against tyrosine kinase EGFR higher than that of Erlotinib.
- Sailaja, B. B. V.,Saritha, B.,kudapa, Venu
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p. 470 - 476
(2022/04/19)
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