144603-44-1

Basic information

• Product Name: (3R)-3,8-dichloro-3-phenylquinoline-2,4(1H,3H)-dione
• CAS NO: 144603-44-1
• Molecular Formula: C₁₅H₉Cl₂NO₂
• Molecular Weight: 306.1435
• Mol File: 144603-44-1.mol

Chemical Properties

• Boiling Point: 507.8°C at 760 mmHg
• Flash Point: 260.9°C
• Density: 1.49g/cm³
• Vapor Pressure: 1.96E-10mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: (3R)-3,8-dichloro-3-phenylquinoline-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-3,8-dichloro-3-phenylquinoline-2,4(1H,3H)-dione(144603-44-1)
• EPA Substance Registry System: (3R)-3,8-dichloro-3-phenylquinoline-2,4(1H,3H)-dione(144603-44-1)

Safety Data

• Hazardous Substances Data: 144603-44-1(Hazardous Substances Data)

Upstream product

• 28563-20-4 8-chloro-4-hydroxy-3-phenyl-1H-quinolin-2-one 
• 144603-87-2 N,N'-Bis-(2-chloro-phenyl)-2-phenyl-malonamide 

Downstream Products

• 144603-72-5 8-Chloro-3-fluoro-3-phenyl-1H-quinoline-2,4-dione 

Relevant articles and documents

Halogenation Reactions in Position 3 of Quinoline-2,4-dione Systems by Electrophilic Substitution and Halogen Exchange

3-Substituted 4-hydroxy-2(1H)-quinolones 3, 5, 7 are halogenated with bromine or sulfuryl chloride to yield the quinolinediones 9 or 10.Reactions of 3, 5, 7 with chloroform gives the dichloromethyl quinolinediones 11.Halogen exchange leads from the chloro quinolinediones 10 to fluoro quinolinedones 12 and to azido quinolinediones 13.Similarly the dichloro quinolinediones 10an reacts to the difluoro quinolinedione 14, which is reduced to the 3-fluoro-4-hydroxyquinolone 16 and reacts again with sulfuryl chloride to give the mixed 3-chloro-3-fluoroquinolinedione 15.Keywords.Fluorination; 4-Hydroxy-2(1H)-quinolones, 3-alkyl/3-aryl/3-fluoro; 1-Hydroxy-benzoquinolizine-3-ones, 2-alkyl/3-aryl; Quinoline-2,4(1H,3H)-diones, 3-azido-3-alkyl/3-aryl, 3-bromo-3-alkyl/3-aryl, 3-chloro-3-alkyl/3-aryl, 3-fluoro-3-alkyl/3-aryl, 3-dichloromethyl-3-alkyl/3-aryl, 3-chloro-3-fluoro.