144625-51-4 Usage
Uses
Used in Pharmaceutical Research:
GR 113808 is used as a serotonin receptor 4 (5-HT4R) blocker for studying its effects on calcium (Ca2+) transients in rat ventricular cardiomyocytes. This application helps researchers understand the role of 5-HT4R in cardiac function and its potential as a therapeutic target for heart-related conditions.
Used in Neuroscience Research:
GR 113808 is used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish. This application aids in understanding the role of 5-HT4R in the development and regeneration of the enteric nervous system, which could have implications for treating gastrointestinal disorders and other related conditions.
Biological Activity
Potent, selective 5-HT 4 receptor antagonist (pK B = 9.43 in human colonic muscle, and K d = 0.15 nM for binding to cloned human 5-HT 4 receptors). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors.
Biochem/physiol Actions
GR 113808 is a 5-HT4 serotonin receptor antagonist.
Check Digit Verification of cas no
The CAS Registry Mumber 144625-51-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,6,2 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 144625-51:
(8*1)+(7*4)+(6*4)+(5*6)+(4*2)+(3*5)+(2*5)+(1*1)=124
124 % 10 = 4
So 144625-51-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
144625-51-4Relevant articles and documents
3-Piperidinylmethylcarboxylate substituted indoles
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, (2008/06/13)
Indole derivatives of formula (I): wherein R1 represents a hydrogen or a halogen atom, or a c1 6alkyl, C1 6alkoxy or hydroxy group;, R2 represents a hydrogen atom or a C1 6alkyl, -CH2C2 5alkenyl or -CH2C2 5alkynyl group;, R3 represents a hydrogen atom or a C1 6alkyl or C1 6alkoxy group;, n represents 2 or 3;, R4 represents a group selected from cyano, hydroxyl, C1 6alkoxy, phenoxy, C(0)C1 6alkyl, C(0)C6H5, -CONR5R6, -NR5COR6, -SO2NR5R6 or -NR5SO2R6 (wherein each of R5 and R6 independently represent a hydrogen atom, a C1 6alkyl or phenyl group);, and quaternary ammonium derivatives, piperidine N-oxides and pharmaceutically acceptable salts and solvates thereof; which compounds are potent and specific antagonists of 5-hydroxytryptamine (5-HT; seretonin).
