144659-13-2 Usage
Uses
Used in Pharmaceutical Industry:
2-(pyridin-2-yl)acetyl chloride is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(pyridin-2-yl)acetyl chloride is employed as a building block for the creation of agrochemicals, enhancing crop protection and contributing to sustainable agriculture.
Used in Dye and Fragrance Industry:
2-(pyridin-2-yl)acetyl chloride is used as a raw material in the production of dyes and fragrances, providing a wide range of colorants and scents for various applications, including textiles, cosmetics, and perfumes.
Used in Organic Synthesis:
As a versatile intermediate, 2-(pyridin-2-yl)acetyl chloride is utilized in organic synthesis for the preparation of a variety of chemical compounds, expanding the scope of chemical research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 144659-13-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,6,5 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 144659-13:
(8*1)+(7*4)+(6*4)+(5*6)+(4*5)+(3*9)+(2*1)+(1*3)=142
142 % 10 = 2
So 144659-13-2 is a valid CAS Registry Number.
144659-13-2Relevant articles and documents
Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2
Nankervis, Jacob L.,Feil, Susanne C.,Hancock, Nancy C.,Zheng, Zhaohua,Ng, Hooi-Ling,Morton, Craig J.,Holien, Jessica K.,Ho, Patricia W.M.,Frazzetto, Mark M.,Jennings, Ian G.,Manallack, David T.,John Martin,Thompson, Philip E.,Parker, Michael W.
supporting information; experimental part, p. 7089 - 7093 (2012/01/06)
PDE4 inhibitors have been identified as therapeutic targets for a variety of conditions, particularly inflammatory diseases. We have serendipitously identified a novel class of phosphodiesterase 4 (PDE4) inhibitor during a study to discover antagonists of the parathyroid hormone receptor. X-ray crystallographic studies of PDE4D2 complexed to four potent inhibitors reveal the atomic details of how they inhibit the enzyme and a notable contrast to another recently reported thiophene-based inhibitor.
