- Enantiomerically enriched bicyclic hydroxamic acids in one step from α-aminohydroxamic acids and keto acids via cyclocondensation
-
New enantiomerically enriched bicyclic hydroxamic acids, 1-hydroxy-dihydro-1Hpyrrolo[ 1,2-a]imidazole-2,5(3H,6H)-diones, have been synthesized by the cyclocondensation of L-α-aminohydroxamic acids with keto acids in a highly chemo- and stereoselective manner. The cis configuration between the amino acid side chain and the methyl group at C7a in 1H-pyrrolo[1,2-a]imidazole-2,5-dione was unambiguously established by X-ray crystallographic analysis. This method could also be applied to the cyclocondensation with o-formylbenzoic acid, giving a tricyclic hydroxamic acid in a good yield. Copyright
- Hoshino, Yujiro,Oyaizu, Masanori,Koyanagi, Yoko,Honda, Kiyoshi
-
-
Read Online