Palladium-catalyzed completely linear-selective negishi cross-coupling of allylzinc halides with aryl and vinyl electrophiles
Completely linear: The title reaction provides an effective means to access a wide range of prenylated arenes and skipped dienes in a completely linear-selective fashion, as demonstrated by a concise synthesis of the anti-HIV natural product siamenol. DFT calculations shed light on the origin of the excellent regioselectivity observed with the current Pd-based catalyst system. Copyright
Yang, Yang,Mustard, Thomas J. L.,Cheong, Paul Ha-Yeon,Buchwald, Stephen L.
Ligand-controlled palladium-catalyzed regiodivergent suzuki-miyaura cross-coupling of allylboronates and aryl halides
An orthogonal set of catalyst systems has been developed for the Suzuki-Miyaura coupling of 3,3-disubstituted and 3-monosubstituted allylboronates with (hetero)aryl halides. These methods allow for the highly selective preparation of either the α- or the
Yang, Yang,Buchwald, Stephen L.
p. 10642 - 10645
(2013/08/23)
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