Alzheimer's disease: Identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS)
The application of dynamic ligation screening (DLS), a methodology for fragment-based drug discovery (FBDD), to the aspartic protease β-secretase (BACE-1) is reported. For this purpose, three new fluorescence resonance energy transfer (FRET) substrates we
Fernandez-Bachiller, Maria Isabel,Horatscheck, Andre,Lisurek, Michael,Rademann, Joerg
p. 1041 - 1056
(2013/07/26)
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