- Genotoxicity assessment of new synthesized acridine derivative - 3,6-diamino-10-methyl-9,10-dihydroacridine
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A new synthesized acridine derivative, 3,6-diamino-10-methyl-9,10-dihydroacridine (AcrH), was tested for in vitro reverse mutations with Salmonella TA strains, chromosome aberrations and sister chromatid exchanges (SCE) in human lymphocytes, and for in vivo chromosome aberrations in bone marrow of mice. Using the classic plate incorporation method, mutagenicity of AcrH in bacterial cells (TA97a, TA98, TA100 and TA102) was observed in the experiments performed with, and without, rat liver S9 metabolic activation. The reverse mutation assay showed no difference in mutagenic activity between AcrH and acriflavine (Acr+) in the test with TA97. The results of in vitro chromosome aberrations assay revealed potential clastogenicity. The test using macroculture of human lymphocytes induced mainly chromatid gaps. The experiments with human lymphocytes revealed SCE-inducing effect of AcrH and Acr+. In an in vivo study, AcrH given intraperitoneally to Balb/c mice did not cause any significant increase in the percentage of cells with aberrations compared to the negative control. Copyright (C) 1999 Elsevier Science B.V.
- Ferenc, Tomasz,Janik-Spiechowicz, Ewa,Bratkowska, Wanda,Lopaczynska, Dobroslawa,Strozynski, Henryk,Denys, Andrzej,Mordalska, Anna
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- Direct characterization of radical species generated on one-electron oxidation of 3,6-diamino-10-methylacridan
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Sequential electron-proton-electron transfer processes in the oxidation of 3,6-diamino-10-methylacridan, an uncharged precursor of acriflavine, were studied. Transient products, i.e., radical cations and radicals, were spectroscopically characterized by pulse radiolysis and laser flash photolysis.
- Marcinek,Zielonka,Adamus,Gebicki,Platz, Matthew S.
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- Efficient and Stable Photocatalytic Systems for Reductive Dechlorination of p-Chlorobiphenyl by Sodium Borohydride
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Acridine Derivatives (9,10-dihydro-10-methylacridine and acriflavine) act as efficient and stable photocatalysts for reductive dechlorination of p-chlorobiphenyl as well as dehalogenation of bromochlorobenzenes with sodium borohydride in acetonitrile/H2O (9:1 v/v) at 298 K.In the case of acriflavine, the limiting quantum yield at irradiation wavelength λ = 350 nm has reached 0.63.
- Ishikawa, Masashi,Fukuzumi, Shunichi
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