- Synthetic method of 4-(2,2-dichloro cyclopropyl)phenol acetate
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The invention discloses a synthetic method of 4-(2,2-dichloro cyclopropyl)phenol acetate. The synthetic method comprises the following steps: taking 2,2-dichloro cyclopropyl benzene as a starting rawmaterial and carrying out electrophilic substitution reaction and baeyer-villiger oxidation reaction to synthesize the 4-(2,2-dichloro cyclopropyl)phenol acetate. According to the preparation method disclosed by the invention, an iodine element-containing co-catalyst is added into the electrophilic substitution reaction to reduce the temperature of the electrophilic substitution reaction, so thatthe selectivity of the electrophilic substitution reaction is improved; the content of an ortho-isomer is reduced within 0.3 percent by adopting relatively-inexpensive acetyl chloride as an electrophilic reagent; the activity of oxidation reaction is improved by adding an iron salt catalyst in the baeyer-villiger oxidation reaction, so that the reaction can be successfully carried out under the condition of taking acetic anhydride as an oxidizing medium, the yield of oxidation reaction is improved and potential safety hazards of a post-treatment process are reduced.
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Paragraph 0052; 0055-0057; 0060-0062; 0065; 0066
(2018/11/03)
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