14494-37-2

Basic information

• Product Name: Cu(II) Protoporphyrin IX
• Synonyms: Cu(II) Protoporphyrin IX
• CAS NO: 14494-37-2
• Molecular Formula: C34H32CuN4O4
• Molecular Weight: 624.18828
• Product Categories: Porphyrins
• Mol File: 14494-37-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cu(II) Protoporphyrin IX(CAS DataBase Reference)
• NIST Chemistry Reference: Cu(II) Protoporphyrin IX(14494-37-2)
• EPA Substance Registry System: Cu(II) Protoporphyrin IX(14494-37-2)

Safety Data

• Hazardous Substances Data: 14494-37-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cu(II) Protoporphyrin IX is used as an antimalaric agent for the treatment of malaria. It works by targeting and destroying the Plasmodium parasites responsible for causing the disease, thus providing a potential solution to combat malaria.
Used in Drug Delivery Systems:
In the field of drug delivery, Cu(II) Protoporphyrin IX is utilized as a carrier for various pharmaceutical compounds. Its biocompatible nature and ability to form micro and nanocapsules make it an ideal candidate for encapsulating drugs, enhancing their delivery, and improving their bioavailability and therapeutic outcomes.
Used in Anticancer Applications:
Although not explicitly mentioned in the provided materials, Cu(II) Protoporphyrin IX could potentially be used in anticancer applications due to its ability to encapsulate and deliver various substances, including chemotherapeutic agents. This could lead to improved treatment options and enhanced efficacy against cancer cells.

Upstream product

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• 553-12-8 protoporphyrin IX 
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• 553-12-8 protoporphyrin IX 
• 553-12-8 protoporphyrin IX 

Relevant articles and documents

Reactions of Copper(I) with Micellar Porphyrins and Hemes. Spectroscopic Evidence for Copper(I)-Heme Binuclear Ion Formation

Addition of cuprous ion to sodium dodecyl sulfate solubilized porphyrins and ferrihemes containing olefinic substituent groups gives rise to spectral perturbations diagnostic of Cu(I) ? complexation.The hemes undergo slow subsequent demetalation in acidic solution, forming porphyrin dications; in the presence of high concentrations of Cu(II) ion the corresponding cupriporphyrins are also formed.For ferriprotoporphyrin IX, the rate of product formation is inversely dependent upon the Cu(II) ion concentration; the data are interpreted in terms of a reaction mechanism, the central feature of which is a dynamic equilibrium between oxidized and reduced hemes, i.e., FeIIIPPIX-CuI + Cu(I) = FeIIPPIX-CuI + Cu(II).This interpretation is supported by the observation that the hemes containing electron-withdrawing substituents in β-pyrrolic positions are extensively reduced to the ferro state by copper(I), but hemes lacking these groups remain primarily ferric when mixed with the cuprous reagent.The reduced Fe(II)-Cu(I) and mixed-valent Fe(III)-Cu(I) binuclear ions are discussed as potential structural models for the oxygen-binding site in cytochrome oxidase.

A copper porphyrin for sensing H2S in aqueous solution via a coordinative-based approach

A turn on fluorescence-based probe for sensing H2S in water via a coordinative-based approach has been successfully devised. The probe can selectively detect H2S in aqueous solutions over other anions, biothiols, and common oxidants such as H2O2. 1H NMR spectroscopy and ESI-MS experiments provide evidence that the turn-on response in the presence of H2S is due to binding of the target anion to the copper center. We devised a new, fast, simple, and cost-effective probe for monitoring hydrogen sulfide. Proof-of-principle results that a copper porphyrin complex can be successfully implemented as a turn-on sensing system for H2S via a coordinative-based approach are reported.

Impact of metal ions in porphyrin-based applied materials for visible-light photocatalysis: Key information from ultrafast electronic spectroscopy

ProtoporphyrinIX-zinc oxide (PP-ZnO) nanohybrids have been synthesized for applications in photocatalytic devices. High-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), and steady-state infrared, absorption, and emission spect

Physicochemical properties of protoporphyrin IX by metal ions in acetonitrile-water mixture solution

The UV-vis absorption spectrum of protoporphyrin IX shows a very sharp and strong absorption maximum peak at 398 nm in acetonitrile-water mixture solution (1:1 v/v). When divalent metal ions such as Cu2+, Zn2+, and Ca2+ ion were added to protoporphyrin IX, metal protoporphyrin IX complexes were thereby produced. Cu-protoporphyrin IX complexes have the largest formation constant (Kf) among them. The fluorescence intensity of protoporphyrin IX was diminished by the presence of Cu2+ , Zn2+ , Ca2+ , Mn2+ , and Ni2+ ions as quenchers. However, Mg2+ , Mn2+ , and Ni 2+ ions are hardly combined with protoporphyrin IX. Mg2+ ion does not take part in the fluorescence quenching process of protoporphyrin IX in acetonitrile-water mixture solution. According to the Stern-Volmer plots, fluorescence quenching by Cu2+ , Zn2+, and Ca2+ ions involves static quenching, which is due to complex formation. On the contrary, dynamic quenching has a large influence on the overall quenching process, when Mn2+ and Ni2+ ions were added to protoporphyrin IX in acetonitrile-water mixture solution.