- Benzyne 1,2,4-Trisubstitution and Dearomative 1,2,4-Trifunctionalization
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Both 1,2,4-trisubstitution and dearomative 1,2,4-trifunctionalization of benzyne have been accomplished from sulfoxides bearing a penta-2,4-dien-1-yl moiety. These cascade transformations proceed through a benzyne insertion into the S═O bond and an uncommon regiospecific anionic [4,5]-sigmatropic rearrangement, furnishing a C-O, C-S, and C-C bond on the C1-, C2-, and C4-position of a benzene ring, respectively. This study showcases new cascade benzyne reaction modes involving both distal C-H bond functionalization and dearomatization.
- Chen, Zhonghong,Dai, Liang,Lan, Yu,Li, Lianggui,Li, Yang,Shan, Chunhui,Shi, Jiarong,Tan, Min
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supporting information
p. 10530 - 10536
(2021/07/28)
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- Tandem thia-Fries rearrangement-cyclisation of 2-(trimethylsilyl)phenyl trifluoromethanesulfonate benzyne precursors
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A novel transformation of 2-(trimethylsilyl)phenyl trifluoromethanesulfonate aryne precursors is described. The Royal Society of Chemistry.
- Hall, Catherine,Henderson, Jaclyn L.,Ernouf, Guillaume,Greaney, Michael F.
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supporting information
p. 7602 - 7604
(2013/09/02)
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