Enantioselective total syntheses of (+)-gallocatechin, (-)- epigallocatechin, and 8-C-ascorbyl-(-)-epigallocatechin
Reading the tea leaves: The enatioselective total syntheses of 8-C-ascorbyl-(-)-epigallocatechin was accomplished by CuII-mediated oxidative coupling of ascorbic acid and (-)-epigallocatechin as a key step. Also, the asymmetric total syntheses of tea-leaf extracts (+)-gallocatechin and (-)-epigallocatechin were achieved by Au-catalyzed intramolecular cycliarylation of the precursor epoxide and Sharpless dihydroxylation. Copyright