144951-50-8

Basic information

• Product Name: 1H-Indole,2-fluoro-1-methyl-(9CI)
• Synonyms: 1H-Indole,2-fluoro-1-methyl-(9CI)
• CAS NO: 144951-50-8
• Molecular Formula: C9H8FN
• Molecular Weight: 149.167
• Product Categories: HALIDE
• Mol File: 144951-50-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole,2-fluoro-1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole,2-fluoro-1-methyl-(9CI)(144951-50-8)
• EPA Substance Registry System: 1H-Indole,2-fluoro-1-methyl-(9CI)(144951-50-8)

Safety Data

• Hazardous Substances Data: 144951-50-8(Hazardous Substances Data)

Usage

Chemical Class

The compound belongs to the indole class of heterocyclic compounds.

Structure

The compound contains an indole ring with a fluorine atom and a methyl group attached to it.

Usage

The compound is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active molecules.

Applications

The compound has potential applications in the field of organic synthesis and materials science.

Unique Properties

The combination of the fluorine and methyl substituents in the indole ring gives this compound interesting chemical and biological properties.

Value

The compound is a valuable tool for the development of new drugs and agricultural chemicals.

Upstream product

• 16136-58-6 N-methyl-1H-indole-2-carboxylic acid 

Relevant articles and documents

Fluoridation of heteroaromatic iodonium salts - Experimental evidence supporting theoretical prediction of the selectivity of the process

Theoretical prediction, that the nucleophilic substitution of a range of arylheteroaryliodonium salts by fluoride ion is regioselective for the aryl ring with the exception of benzo[b]furan, are borne out by experimental observation.

Decarboxylative Fluorination of Electron-Rich Heteroaromatic Carboxylic Acids with Selectfluor

A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic acids, such as indole and pyrazole. An effective method has been developed to synthesize the monomer of 2- and 3-fluoroindoles with Li2CO3 as base at low temperature.