- Catalytic Hydroamination of Furfuryl and Tetrahydrofurfuryl Alcohols with Nitriles
-
Reaction of furfuryl and tetrahydrofurfuryl alcohols with nitriles over copper oxide catalysts under a hydrogen pressure of 15 atm at a temperature of 230 deg C gives N-alkylfurfuryl- (yield 46-50percent) and N-alkyltetrahydrofurfurylamines (49-53percent), and N-alkylpiperidines (28-41percent).A reaction mechanism is proposed.
- Kozintsev, S. I.,Basalaeva, L. I.,Gladkikh, L. V.,Kozlov, N. S.
-
-
Read Online
- Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines
-
Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.
- An, Duk Keun,Jaladi, Ashok Kumar,Kim, Hyun Tae,Yi, Jaeeun
-
-