- A novel benzochalcones and composition for anticancer comprising the same
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The present invention refers to same derivatives and including novel benzo knife cone is directed to anticancer composition.
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Paragraph 0033; 0054; 0055; 0061
(2016/12/07)
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- Complete assignments of 1H and 13C NMR data for 21 naphthalenyl-phenyl-pyrazoline derivatives
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To find potent new chemotherapy drugs, we designed and synthesized a series of naphthochalcones bearing naphthalenyl-phenyl-pyrazoline moieties. The complete 1H and 13C NMR data for these compounds are reported here and can be used t
- Hwang, Doseok,Yoon, Hyuk,Ahn, Seunghyun,Kim, Dong-Wook,Bae, Dong-Ho,Koh, Dongsoo,Lim, Yoongho
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p. 593 - 599
(2013/09/02)
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- 1H and 13C NMR spectral assignments of chalcones bearing pyrazoline-carbothioamide groups
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Chalcones are known to act on various physiological targets. As a result, structural modifications of chalcones have been studied extensively. Benzochalcones, in which the A-ring of chalcone is substituted with a naphthalene unit, inhibits breast cancer resistance protein. Chalcones in which the α,β-unsaturated carbonyl group is switched with a pyrazoline moiety are potent cytotoxic agents against various cancer cell lines, and chalcones with a pyrazoline-1-carbothioamide group instead of an α,β-unsaturated carbonyl group exhibit antimicrobial activities. The present report describes hybrid molecules designed from benzochalcone and pyrazoline-carbothioamide. Methoxylation of plant-derived polyphenols alters their hydrophobicity, resulting in changes in biological function and intracellular compartmentation. In the current study, 22 novel methoxylated 3-(naphthalen-2-yl)-N,5-diphenyl-pyrazoline-1-carbothioamide derivatives were prepared. This report provides complete assignments of their 1H and 13C NMR data, which can be used to subsequently identify chalcones bearing pyrazoline-carbothioamide groups. Copyright
- Yoon, Hyuk,Ahn, Seunghyun,Park, Mijoo,Kim, Dong-Wook,Kim, Sang Ho,Koh, Dongsoo,Lim, Yoongho
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p. 500 - 508
(2013/07/26)
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