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144989-41-3

4,6-Dichloro-2-(ethoxycarbonyl)-1H-indole-3-propanoic acid is an organic compound with a complex molecular structure, characterized by the presence of a 1H-indole-3-propanoic acid core with chloro and ethoxycarbonyl substitutions. This molecule exhibits unique chemical properties and has been identified for its potential applications in various fields.

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  • 144989-41-3 Structure

  • Basic information

    1. Product Name: 4,6-Dichloro-2-(ethoxycarbonyl)-1H-indole-3-propanoic acid
    2. Synonyms: 4,6-Dichloro-2-(ethoxycarbonyl)-1H-indole-3-propanoic acid
    3. CAS NO:144989-41-3
    4. Molecular Formula: C14H13Cl2NO4
    5. Molecular Weight: 330.16
    6. EINECS: N/A
    7. Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 144989-41-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.473
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4,6-Dichloro-2-(ethoxycarbonyl)-1H-indole-3-propanoic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4,6-Dichloro-2-(ethoxycarbonyl)-1H-indole-3-propanoic acid(144989-41-3)
    11. EPA Substance Registry System: 4,6-Dichloro-2-(ethoxycarbonyl)-1H-indole-3-propanoic acid(144989-41-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 144989-41-3(Hazardous Substances Data)

144989-41-3 Usage

Uses

Used in Pharmaceutical Industry:
4,6-Dichloro-2-(ethoxycarbonyl)-1H-indole-3-propanoic acid is used as a fructose-1,6-bisphosphatase inhibitor for its ability to regulate the activity of this enzyme, which plays a crucial role in glucose metabolism. By inhibiting fructose-1,6-bisphosphatase, this compound can potentially be utilized in the development of treatments for conditions related to glucose metabolism dysregulation, such as diabetes.
Used in Research Applications:
In the field of scientific research, 4,6-Dichloro-2-(ethoxycarbonyl)-1H-indole-3-propanoic acid serves as a valuable tool for studying the role of fructose-1,6-bisphosphatase in cellular processes and its implications in various diseases. Researchers can use this compound to investigate the enzyme's function and develop a deeper understanding of its involvement in glucose metabolism and related pathologies.
Used in Drug Development:
The identification of 4,6-Dichloro-2-(ethoxycarbonyl)-1H-indole-3-propanoic acid as a fructose-1,6-bisphosphatase inhibitor opens up opportunities for its application in the development of novel therapeutic agents. By further exploring its inhibitory properties and potential synergistic effects with other compounds, this molecule could be a key component in the creation of new drugs targeting glucose metabolism-related disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 144989-41-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,9,8 and 9 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 144989-41:
(8*1)+(7*4)+(6*4)+(5*9)+(4*8)+(3*9)+(2*4)+(1*1)=173
173 % 10 = 3
So 144989-41-3 is a valid CAS Registry Number.

144989-41-3Downstream Products

144989-41-3Relevant articles and documents

3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: An allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site

Wright, Stephen W.,Carlo, Anthony A.,Danley, Dennis E.,Hageman, David L.,Karam, George A.,Mansour, Mahmoud N.,McClure, Lester D.,Pandit, Jayvardhan,Schulte, Gayle K.,Treadway, Judith L.,Wang, Ing-Kae,Bauer, Paul H.

, p. 2055 - 2058 (2003)

3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to be an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. The compound binds at the AMP regulatory site by X-ray crystallography. This represents a new approach to inhibition of fructose 1,6-bisphosphatase and serves as a lead for further drug design.

Improved synthesis of 4-/6-substituted 2-carboxy-1H-indole-3-propionic acid derivatives and structure-activity relationships as GPR17 agonists

Baqi, Younis,Alshaibani, Samer,Ritter, Kirsten,Abdelrahman, Aliaa,Spinrath, Andreas,Kostenis, Evi,Mueller, Christa E.

, p. 86 - 92 (2014/01/06)

The orphan G protein-coupled receptor GPR17 was shown to be involved in myelin repair and has been proposed as a novel drug target for the treatment of brain and spinal cord injury and for multiple sclerosis. Recently, 3-(2-carboxy-4,6-dichloro-indol-3-yl

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