Enantiomerization kinetics studied by dynamic enantioselective liquid chromatography: Solvent, temperature and stationary phase effects on the rate of N-benzyl-1,3,2-benzodithiazole 1-oxide enantiomer interconversion
Enantiomerization of 1 was found to proceed ca. 10 times faster in hexane than in methanol. This has been attributed to the difference in ΔS? found in the respective solvents. The presence of a chiral HPLC stationary phase (Whelk-Ol) did not affect the rate of enantiomerization to any significant extent. The previously determined enantiomerization (by inversion of configuration) barrier of 2 using DHPLC (80 kJ mol-1), is thus considered correct, and not biased by the presence of the stationary phase.
Oxelbark, Joakim,Allenmark, Stig
p. 1587 - 1589
(2007/10/03)
Synthesis and Antifungal Activity of 1,3,2-Benzodithiazole S-Oxides
The preparation of 1,3,2-benzodithiazole S-oxide analogs exhibiting in vitro antifungal activity against several strains of Candida is described.For the preparation of derivatives bearing aromatic substituents, a novel electrophilic aromatic thiolation re
Klein, Larry L.,Yeung, Clinton M.,Weissing, David E.,Lartey, Paul A.,Tanaka, S. Ken,et al.
p. 572 - 578
(2007/10/02)
1,3,2-benzodithiazole-1-oxide compounds
Novel 1,3,2-benzodithiazole-1-oxides of formula (I) STR1 and their pharmaceutically acceptable salts are disclosed, wherein R1 is a substituent on the 4-, 5-, 6- or 7-position of the benzodithiazole nucleus selected from the group consisting of
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(2008/06/13)
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