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CAS

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1450655-76-1

CPI-169 is a heteroaryl amide that has been discovered to be useful as a modulator of Me modifying enzymes. It is a promising compound with potential applications in various industries due to its ability to interact with and modulate the activity of certain enzymes.

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  • 1450655-76-1 Structure

  • Basic information

    1. Product Name: CPI-169
    2. Synonyms: CPI-169;CPI-169 racemate;1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide
    3. CAS NO:1450655-76-1
    4. Molecular Formula: C27H36N4O5S
    5. Molecular Weight: 528.66354
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1450655-76-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.31±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: ≥26.45 mg/mL in DMSO; insoluble in H2O; ≥2.18 mg/mL in EtOH with gentle warming and ultrasonic
    9. PKA: 11.01±0.10(Predicted)
    10. CAS DataBase Reference: CPI-169(CAS DataBase Reference)
    11. NIST Chemistry Reference: CPI-169(1450655-76-1)
    12. EPA Substance Registry System: CPI-169(1450655-76-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1450655-76-1(Hazardous Substances Data)

1450655-76-1 Usage

Uses

Used in Pharmaceutical Industry:
CPI-169 is used as a modulator for Me modifying enzymes for the development of novel therapeutic strategies. Its ability to interact with and modulate the activity of these enzymes makes it a valuable candidate for the treatment of various diseases and conditions.
Used in Research and Development:
CPI-169 is used as a research tool to study the role and function of Me modifying enzymes in cellular processes. This can help researchers gain a better understanding of the underlying mechanisms of certain diseases and develop targeted therapies.
Used in Drug Discovery:
CPI-169 is used as a starting point for the development of new drugs that target Me modifying enzymes. Its unique properties and interactions with these enzymes make it a valuable compound for the design and synthesis of novel therapeutic agents.

Biological Activity

cpi-169 is a novel, small molecule and potent inhibitor of enhancer of zeste homolog 2 (ezh2) with an ic50 value of <1nm for polycomb repressive complex 2 (prc2) [1].cpi-169 has been found to be a potent ezh2 inhibitor with an ic50 value of <1nm for polycomb repressive complex 2 (prc2). in addition, cpi-169 has been reported to reduce cellular levels of histone h3 on lysine 27(h3k27) with an ec50 value of 70nm. moreover, cpi-169 has been exhibited to trigger cell cycle arrest and apoptosis in cells. apart from these, treatment the inhibitor at 200mpk twice daily, cpi-169 has been noted to have a well tolerated in mice with no observed toxic effect or body weight loss [1].

references

[1] vidya balasubramanian, priya iyer, shilpi arora, patrick troyer, emmanuel normant. constellation pharmaceuticals, cambridge, ma. cpi-169, a novel and potent ezh2 inhibitor, synergizes with chop in vivo and achieves complete regression in lymphoma xenograft models

Check Digit Verification of cas no

The CAS Registry Mumber 1450655-76-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,0,6,5 and 5 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1450655-76:
(9*1)+(8*4)+(7*5)+(6*0)+(5*6)+(4*5)+(3*5)+(2*7)+(1*6)=161
161 % 10 = 1
So 1450655-76-1 is a valid CAS Registry Number.

1450655-76-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2- methyl-1H-indole-3-carboxamide

1.2 Other means of identification

Product number -
Other names 1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1450655-76-1 SDS

1450655-76-1Upstream product

1450655-76-1Downstream Products

1450655-76-1Relevant articles and documents

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

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Paragraph 0086; 0087, (2014/08/20)

Agents having the structural Formula (II) for modulating histone methyl modifying enzymes, compositions and uses thereof for instance as anti-cancer agents are provided herein.

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