- Processes for the preparation of hydroquinone and benzoquinone derivatives
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Intermediates for the preparation of benzothiazole derivatives useful for the prevention and treatment of diseases for which an inhibitory action against the production of leukotriene and thromboxane is efficacious, and industrially advantageous processes
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- Synthesis of a novel dual inhibitor of thromboxane A2 synthetase and 5- lipoxygenase (E3040) via the direct coupling reaction of hydroquinone with 3- pyridinecarboxaldehyde
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Synthesis of a novel dual inhibitor of thromboxane A2 synthetase and 5- lipoxygenase, 5,7-dimethyl-6-hydroxy-2-methylamino-4-(3- pyridylmethyl)benzothiazole (E3040), was accomplished via a new coupling reaction, in which a key intermediate, (3,6-dihydroxy-2,4-dimethylphenyl)- (3-pyridyl)methanol, was easily synthesized in a high yield from 2,6- dimethyl-1,4-benzohydroquinone and 3-pyridinecarboxaldehyde in 6 N hydrochloric acid. The regio isomers of 3-pyridinecarboxaldehyde also gave the corresponding coupling products in high yields.
- Komatsu,Minami
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p. 1614 - 1616
(2007/10/03)
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- PYRIDYL SUBSTITUTED BENZOTHIAZOLE COMPOUNDS WHICH HAVE USEFUL PHARMACEUTICAL UTILITY
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A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective. A benzothiazole derivativ
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- Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: Synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives
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As part of our search for novel antiinflammatory drug candidates, we have designed and synthesized a series of 3-pyridylmethyl-substituted 2-amino-6- hydroxybenzothiazoles. Introduction of a 3-pyridylmethyl group into the 2- amino group (type-A) or the be
- Hibi,Okamoto,Tagami,Numata,Kobayashi,Shinoda,Kawahara,Murakami,Oketani,Inoue,Shibata,Yamatsu
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p. 3062 - 3070
(2007/10/02)
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