145127-37-3

Basic information

• Product Name: Methyl 3-morpholin-4-yl-benzoate
• Synonyms: Methyl 3-morpholin-4-yl-benzoate;3-(4-morpholinyl)Benzoic acid ethyl ester;Ethyl 3-morpholinobenzoate
• CAS NO: 145127-37-3
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.28
• Product Categories: pharmacetical
• Mol File: 145127-37-3.mol

Chemical Properties

• Boiling Point: 371.9°Cat760mmHg
• Flash Point: 178.7°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 9.98E-06mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 3-morpholin-4-yl-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-morpholin-4-yl-benzoate(145127-37-3)
• EPA Substance Registry System: Methyl 3-morpholin-4-yl-benzoate(145127-37-3)

Safety Data

• Hazardous Substances Data: 145127-37-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 3-morpholin-4-yl-benzoate is used as an intermediate in the production of pharmaceuticals for its ability to contribute to the synthesis of various organic compounds, enhancing the development of new drugs and medications.
Used in Chemical Reactions:
Methyl 3-morpholin-4-yl-benzoate is used as a solvent in various chemical reactions and processes, facilitating the progress of these reactions and contributing to the efficiency of chemical production.
Used in Chemical Industry:
Methyl 3-morpholin-4-yl-benzoate is utilized in the chemical industry for its stability and versatility, playing a crucial role in the synthesis and production of a range of organic compounds.

InChI:InChI=1/C12H15NO3/c1-15-12(14)10-3-2-4-11(9-10)13-5-7-16-8-6-13/h2-4,9H,5-8H2,1H3

Upstream product

• 110-91-8 morpholine 
• 24398-88-7 ethyl 3-bromobenzoate 
• 451-02-5 ethyl 3-fluorobenzoate 
• 58313-23-8 3-iodobenzoic acid methyl ester 
• 33668-25-6 ethyl 3-oxocyclohexanecarboxylate 

Downstream Products

• 215309-00-5 3-(4-morpholinyl)benzoic acid 

Relevant articles and documents

Electrochemical Cross-Dehydrogenative Aromatization Protocol for the Synthesis of Aromatic Amines

The introduction of amines onto aromatics without metal catalysts and chemical oxidants is synthetically challenging. Herein, we report the first example of an electrochemical cross-dehydrogenative aromatization (ECDA) reaction of saturated cyclohexanones and amines to construct anilines without additional metal catalysts and chemical oxidants. This reaction exhibits a broad scope of cyclohexanones including heterocyclic ketones, affording a variety of aromatic amines with various functionalities, and shows great potential in the synthesis of biologically active compounds.

Benzimidazole compound, preparation method thereof and application of the benzimidazole compound in preparation of ferroptosis inhibitor

The invention discloses a benzimidazole compound, a preparation method thereof and application of the benzimidazole compound in preparation of a ferroptosis inhibitor. The benzimidazole compound has a structure as shown in a formula (I) or a formula (II)

Metal-free Synthesis of Aryl Amines: Beyond Nucleophilic Aromatic Substitution

A mild and metal-free approach to C?N coupling is described that employs diaryliodonium salt electrophiles and secondary aliphatic amine nucleophiles. This reaction results in direct ipso-substitution of the iodonium moiety and unsymmetrical aryl(TMP)iodonium salts are primarily employed. Moreover, arene substituents and substitution patterns that currently pose a challenge to classical metal-free methods are accommodated and the alicyclic amine nucleophiles used here are unprecedented in other contemporary metal-free C?N coupling reactions.

Study of a new rate increasing "base effect" in the palladium-catalyzed amination of aryl iodides

Evidence for an interphase deprotonation of Pd(II)-amine complexes with weak carbonate base has been gained for the first time. When a rate-limiting deprotonation step is involved in the catalytic cycle, controlling the structure (shape and size of the particles) and/or molar excess of the carbonate base used can significantly increase the reaction rate of Buchwald-Hartwig aminations. By taking such a "base effect" into account a general protocol for the intermolecular amination of aryl iodides with all types of amines has been developed based on a standard Pd-BINAP catalyst, using cesium carbonate as the base.

Synthesis of meta-substituted aniline derivatives by nucleophilic substitution

Substitution by amines of fluorobenzenes containing a meta- substituted electron withdrawing group (EWG), in DMSO at 100 °C over 60 h gave meta-substituted aniline derivatives in isolated yields of up to 98%. The scope of the reaction is explored in terms of reaction conditions and substrates. It is postulated that facile meta-substitutions are facilitated through field stabilisation of the intermediate anion by EWG substituents.