14517-44-3

Basic information

• Product Name: H-MET-GLU-OH
• Synonyms: L-METHIONYL-L-GLUTAMIC ACID;L-MET-GLU;H-MET-GLU-OH;met-glu;L-Met-L-Glu-OH;Met-Glu-OH;N-L-Methionyl-L-glutamic acid
• CAS NO: 14517-44-3
• Molecular Formula: C₁₀H₁₈N₂O₅S
• Molecular Weight: 278.33
• Mol File: 14517-44-3.mol

Chemical Properties

• Melting Point: 205-206 °C
• Boiling Point: 583.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.343±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 2.98±0.10(Predicted)
• CAS DataBase Reference: H-MET-GLU-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-MET-GLU-OH(14517-44-3)
• EPA Substance Registry System: H-MET-GLU-OH(14517-44-3)

Safety Data

• Hazardous Substances Data: 14517-44-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
H-MET-GLU-OH is used as a therapeutic agent for the treatment of central nervous system disorders and neurodegenerative diseases due to its potential neuroprotective and neuroregenerative properties.
Used in Research and Development:
H-MET-GLU-OH serves as a valuable tool in the study of protein structure and function, given its enhanced stability and conformational properties resulting from the N-methylation of the glutamic acid moiety. This makes it instrumental in advancing our understanding of protein dynamics and their implications in health and disease.

Upstream product

• 63-68-3 L-methionine 
• 80714-61-0 H-Met-Glu-His-Phe-Pro-Gly-Pro 
• 115944-77-9 N-(N-benzyloxycarbonyl-L-methionyl)-L-glutamic acid diethyl ester 
• 1152-62-1 Cbz-Met-OH 
• 98398-16-4 (2S)-2-{[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-(methylsulfanyl)butanoyl]amino}pentanedioic acid 

Downstream Products

• 114795-73-2 N-[N-(N-benzyloxycarbonyl-L-seryl)-L-methionyl]-L-glutamic acid 
• 116913-09-8 N-benzyloxycarbonyl-seryl=>tyrosyl=>methionyl=>glutamic acid 

Relevant articles and documents

Studies of the aminopeptidase proteolysis of semax analogues with different N-terminal amino acid residues

Proteolysis of semax (Met-Glu-His-Phe-Pro-Gly-Pro, Sem) and its analogues with the substitution of Ala, Gly, Thr, or Trp for the N-terminal Met was studied. This substitution was shown to change the degradation rate of these peptides by leucine aminopeptidase (EC 3.4.11.2, Sigma, Type VI, 9.2 activity units/mg). [Ala1]Sem, [Gly1]Sem, and [Thr1]Sem (the semax analogues) proved to be more stable to the proteolysis than semax itself. It was demonstrated that the primary product of the proteolysis was His-Phe-Pro-Gly-Pro (Sem-5). In the case of [Trp1]Sem, the comparable amount of Glu-His-Phe-Pro-Gly-Pro (Sem-6) was found to be formed along with Sem-5. In was established that all the studied semax analogues could be used as inhibitors of its proteolysis. Pleiades Publishing, Ltd., 2011.

Activation of recombinant proteins

A process for the activation of recombinant proteins which are present in at least a partially inactive form in which a protein is activated by known solubilization or/and renaturation techniques, said protein having additional helper sequences 2 to 50 amino acids in length at its N- or/and C-terminus whereby the relative hydrophobicity of these helper sequences which is calculated as the sum of the relative hydrophobicity specified in Table 1 for the individual amino acids has a negative numerical value.