Lessons from (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3- b ]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-met with high protein kinase selectivity but broad phosphodiesterase family inhibition lea
The hepatocyte growth factor (HGF)/c-Met signaling axis is deregulated in many cancers and plays important roles in tumor invasive growth and metastasis. An exclusively selective c-Met inhibitor (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)- [1,2,4]triazolo[4,3-
Cui, J. Jean,Shen, Hong,Tran-Dubé, Michelle,Nambu, Mitchell,McTigue, Michele,Grodsky, Neil,Ryan, Kevin,Yamazaki, Shinji,Aguirre, Shirley,Parker, Max,Li, Qiuhua,Zou, Helen,Christensen, James
p. 6651 - 6665
(2013/10/01)
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