145304-36-5

Basic information

• Product Name: Benzoyl chloride, 4-(2-fluoroethoxy)- (9CI)
• Synonyms: Benzoyl chloride, 4-(2-fluoroethoxy)- (9CI);4-(2-Fluoro-ethoxy)-benzoyl chloride
• CAS NO: 145304-36-5
• Molecular Formula: C₉H₈ClFO₂
• Molecular Weight: 202.6100232
• Product Categories: ACIDHALIDE
• Mol File: 145304-36-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoyl chloride, 4-(2-fluoroethoxy)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 4-(2-fluoroethoxy)- (9CI)(145304-36-5)
• EPA Substance Registry System: Benzoyl chloride, 4-(2-fluoroethoxy)- (9CI)(145304-36-5)

Safety Data

• Hazardous Substances Data: 145304-36-5(Hazardous Substances Data)

Upstream product

• 99-96-7 4-hydroxy-benzoic acid 
• 2967-92-2 4-(2-fluoro-ethoxy)-benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 145304-35-4 4-(2-fluoroethoxyl)benzoic acid 

Downstream Products

• 872041-20-8 1-(3-bromo-4-fluorophenyl)-2-[4-(2-fluoroethoxy)-phenyl]ethane-1,2-dione 
• 1567375-90-9 2-(4-(2-fluoroethoxy)phenyl)-1H-benzo[d]imidazole-4-carboxamide 
• 1567375-88-5 methyl 2-(4-(2-fluoroethoxy)phenyl)-1H-benzo[d]imidazole-4-carboxylate 
• 1567375-93-2 5,6-dihydro-2-(4-(2-fluoroethoxy)phenyl)-imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one 

Relevant articles and documents

Structure-Function Evaluation of Imidazopyridine Derivatives Selective for δ-Subunit-Containing γ-Aminobutyric Acid Type A (GABAA) Receptors

δ-Selective compounds 1 and 2 (DS1, compound 22; DS2, compound 16) were introduced as functionally selective modulators of δ-containing GABA type A receptors (GABAAR). In our hands, [3H]EBOB-binding experiments with recombinant GABAAR and compound 22 showed no proof of δ-selectivity, although there was a minimally higher preference for the α4β3δ and α6β2/3δ receptors with respect to potency. In order to delineate the structural determinants of δ preferences, we synthesized 25 derivatives of DS1 and DS2, and investigated their structure-activity relationships (SAR). Four of our derivatives showed selectivity for α6β3δ receptors (29, 38, 39, and 41). For all of them, the major factors that distinguished them from compound 22 were variations at the para-positions of their benzamide groups. However, two compounds (29 and 39), when tested in the presence of GABA, revealed effects at several additional GABAAR. The newly synthesized compounds will still serve as useful tools to investigate α6β3δ receptors.

The flocculated acryloyldimethyltauric molecule ligand

Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.

Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase

The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated β-amyloid deposits or β-amyloid levels in a patient.