145440-89-7 Usage
Structural components
Isoxazole ring: This heterocyclic ring consists of four carbon atoms, one oxygen atom, and one nitrogen atom, forming a five-membered ring.
Carboxamide group: This functional group consists of a carbonyl group (C=O) bonded to an amine group (-NH?).
Dimethylphenyl group: A phenyl group (C?H?) with two methyl (CH?) substituents attached to positions 2 and 6.
Phenyl group: A benzene ring (C?H?) attached to the nitrogen atom of the carboxamide group.
Potential applications
Pharmaceutical research: Due to its unique chemical structure, it may exhibit pharmacological activities that could be explored for potential drug development.
Interest for researchers
Synthesis: Methods for synthesizing 3-Isoxazolecarboxamide, N-(2,6-dimethylphenyl)-5-phenyl- may be of interest to organic chemists.
Characterization: Analyzing the physical and chemical properties of 3-Isoxazolecarboxamide, N-(2,6-dimethylphenyl)-5-phenyl- could provide insights into its reactivity and potential applications in medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 145440-89-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,4,4 and 0 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 145440-89:
(8*1)+(7*4)+(6*5)+(5*4)+(4*4)+(3*0)+(2*8)+(1*9)=127
127 % 10 = 7
So 145440-89-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H16N2O2/c1-12-7-6-8-13(2)17(12)19-18(21)15-11-16(22-20-15)14-9-4-3-5-10-14/h3-11H,1-2H3,(H,19,21)
145440-89-7Relevant articles and documents
New N-aryl isoxazolecarboxamides and N-isoxazolylbenzamides as anticonvulsant agents
Lepage,Tombret,Cuvier,Marivain,Gillardin
, p. 581 - 593 (2007/10/02)
We prepared a series of N-aryl isoxazolecarboxamide, N-isoxazolylbenzamide compounds and derivatives and studied their anticonvulsant action in MES and MMS tests. Some of these reveal considerable activity, especially with respect to MES test. The disubstitution in the 2.6-position on the phenyl ring by two methyl groups would appear to be of primary importance for the activity. The amide bridge between the phenyl and isoxazolic rings, whether of the anilide or benzamide type, seems to show similar anticonvulsant behavior. We have selected the derivatives 8 (N-(2.6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide, 12 (N-(2.6-dimethylphenyl)-5-hydroxymethyl-3-isoxazolecarboxamide) and 51 (N-(5-methyl-3-isoxazolyl)-2.6-dimethylbenzamide) which are presently being studied in more extended pharmacological tests.
