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145594-64-5

(2R)-2-hydroxypropyl methyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is a chemical compound belonging to the dihydropyridine class. It is a derivative of nitrendipine, a calcium channel blocker used for treating hypertension and angina. (2R)-2-hydroxypropyl methyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate features two chiral centers with (2R) and (4S) configurations, and the presence of hydroxypropyl methyl and nitrophenyl groups in its structure enhances its pharmacological activity. It is likely to exhibit calcium channel blocking activity and may have potential therapeutic applications in cardiovascular disease treatment. Its unique chemical structure and properties make it a promising candidate for further research and development in medicinal chemistry.

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  • 5-O-[(2R)-2-hydroxypropyl] 3-O-methyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

    Cas No: 145594-64-5

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  • 145594-64-5 Structure

  • Basic information

    1. Product Name: (2R)-2-hydroxypropyl methyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
    2. Synonyms:
    3. CAS NO:145594-64-5
    4. Molecular Formula: C19H22N2O7
    5. Molecular Weight: 390.3872
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 145594-64-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 549.1°C at 760 mmHg
    3. Flash Point: 285.9°C
    4. Appearance: N/A
    5. Density: 1.287g/cm3
    6. Vapor Pressure: 6.82E-13mmHg at 25°C
    7. Refractive Index: 1.564
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: (2R)-2-hydroxypropyl methyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: (2R)-2-hydroxypropyl methyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate(145594-64-5)
    12. EPA Substance Registry System: (2R)-2-hydroxypropyl methyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate(145594-64-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 145594-64-5(Hazardous Substances Data)

145594-64-5 Usage

Uses

Used in Pharmaceutical Industry:
(2R)-2-hydroxypropyl methyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is used as a calcium channel blocker for the treatment of hypertension and angina due to its ability to block calcium channels, leading to vasodilation and reduced blood pressure.
Used in Medicinal Chemistry Research:
(2R)-2-hydroxypropyl methyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate serves as a subject of interest for further research and development in the field of medicinal chemistry, given its potential therapeutic applications and unique chemical structure. It may lead to the discovery of new drugs or drug candidates for the treatment of cardiovascular diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 145594-64-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,5,9 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 145594-64:
(8*1)+(7*4)+(6*5)+(5*5)+(4*9)+(3*4)+(2*6)+(1*4)=155
155 % 10 = 5
So 145594-64-5 is a valid CAS Registry Number.

145594-64-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-O-[(2R)-2-hydroxypropyl] 3-O-methyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

1.2 Other means of identification

Product number -
Other names MP3689

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:145594-64-5 SDS

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