- Preparation method of latanoprost
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The invention provides a preparation method of latanoprost. Compared with methods in the prior art, the method has the advantages of few steps, high yield, high product purity, avoidance of a hydrogenation reduction process and a chiral reduction or chiral resolution process, great reduction of the cost, improvement of the safety, small discharge amount of three wastes, high environmental protection property, and especially suitable for industrial application to produce latanoprost.
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Paragraph 0038-0041
(2021/04/07)
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- IMPROVED PROCESS FOR THE PREPARATION OF PROSTAGLANDINS AND ANALOGUES THEREOF
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The present invention relates to an improved process for the preparation of prostaglandin and prostaglandin analogues, particularly PGF2α derivatives.
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Page/Page column 15
(2010/11/03)
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- Ligand-controlled palladium-catalyzed intramolecular reactions of phenyl-substituted prostaglandin P(2α) analogues
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Palladium catalyzed intramolecular cyclization of the 15R and 15S epimers of 17-(2-iodophenyl)-18,19,20-trinorprostaglandin F(2α) isopropylester [(15R)-5 and (15S)-5, respectively] produce a complex mixture of products including various tetrahydronaphthol
- Liljebris,Resul,Hacksell
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p. 9139 - 9154
(2007/10/02)
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- Phenyl-Substituted Prostaglandins: Potent and Selective Antiglaucoma Agents
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A series of phenyl-substituted analoques of prostaglandin F2α (PGF2α) were prepared and evaluated for ocular hypotensive effect and side effects in different animal models.In addition, the activity of the analogues on FP receptors was studied in vitro.The results were compared with those of PGF2α and its isopropyl ester.The phenyl-substituted PGF2α analogues exhibited good intraocular pressure reducing effect, were more selective, and exhibited a much higher therapeutic index in the eye than PGF2α or its isopropyl ester.The analogues exhibited high activity on FP receptors in a stereoselective manner for the 15a-hydroxyl group.
- Resul, Bahram,Stjernschantz, Johan,No, Kiyo,Liljebris, Charlotta,Selen, Goeran,et al.
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p. 243 - 248
(2007/10/02)
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