- TiCl4 mediated facile synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles
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An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope.
- Zhang, Lin,Yu, Yu,Tang, Qiang,Yuan, Jianyong,Ran, Dongzhi,Tian, Binghua,Pan, Tao,Gan, Zongjie
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p. 423 - 431
(2019/12/27)
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- Phenyl oxime derivative and preparation method and application thereof
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The invention relates to a phenyl oxime derivative as well as a preparation method and application thereof. Specifically, the present invention relates to a phenyl oxime derivative represented by formula (I) or a stereoisomer of the phenyl oxime derivativ
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Paragraph 0120-0121
(2020/12/31)
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- Microwave promoted one-pot synthesis of 2-aryl substituted 1,3,4-oxadiazoles and 1,2,4-oxadiazole derivatives using Al3+-K10 clay as a heterogeneous catalyst
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An efficient, inexpensive method is developed for the one-pot synthesis of 2-aryl substituted 1,3,4-oxadiazoles and 1,2,4-oxadiazoles starting from acid hydrazides and trimethyl orthoformate under solvent-free, microwave conditions using a reusable Alsup
- Suresh, Dhanusu,Kanagaraj, Kuppusamy,Pitchumani, Kasi
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supporting information
p. 3678 - 3682
(2014/06/23)
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- One-pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles based on the reaction of N,N-dimethyl amides with acid hydrazides
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Convenient and efficient one pot method for the synthesis of 2,5-disubstituted-1,3,4-oxadiazoles based on the reaction of N,N-dimethyl amides with acid hydrazides has been developed. The methodology is applied to a wide range of difference aryl hydrazide and difference N,N-dimethyl amides to 2,5-disubstituted-1,3,4-oxadiazoles yield the in good to excellent yields. It will be possible wide useful application in synthesis. Synopsis Convenient and efficient one pot method for the synthesis of 2,5-disubstituted-1,3,4- oxadiazoles based on the reaction of N,N-dimethyl amides with acid hydrazides has been developed. The methodology is applied to a wide range of difference aryl hydrazide and difference N,N-dimethyl amides to 2,5-disubstituted- 1,3,4-oxadiazoles yield the in good to excellent yields. It will be possible wide useful application in synthesis. Copyright
- Li, Qiang,Tao, Yi,Xu, Dongfang,Zhang, Haobing,Duan, Liping
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p. 665 - 670
(2014/06/24)
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- HETEROCYCLIC AMIDES AS KINASE INHIBITORS
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Disclosed are compounds having the formula (I) wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.
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Page/Page column 115
(2014/09/03)
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- P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K
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An orally bioavailable series of ketoamide-based cathepsin K inhibitors with good pharmacokinetic properties has been identified. Starting from a potent inhibitor endowed with poor drug properties, conformational constraint of the P2-P3 linker and modifications to P1′ elements led to an enhancement in potency, solubility, clearance, and bioavailability. These optimized inhibitors attenuated bone resorption in a rat TPTX hypocalcemic bone resorption model.
- Barrett, David G.,Boncek, Virginia M.,Catalano, John G.,Deaton, David N.,Hassell, Anne M.,Jurgensen, Cynthia H.,Long, Stacey T.,McFadyen, Robert B.,Miller, Aaron B.,Miller, Larry R.,Payne, J. Alan,Ray, John A.,Samano, Vicente,Shewchuk, Lisa M.,Tavares, Francis X.,Wells-Knecht, Kevin J.,Willard Jr., Derril H.,Wright, Lois L.,Zhou, Hui-Qiang Q.
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p. 3540 - 3546
(2007/10/03)
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