Synthesis of 3-(thiazol-4-yl)alanine and 3-(selenazol-4-yl)alanine derivatives from aspartic acid
3-(Thiazol-4-yl)alanine as well as 3-(selenazol-4-yl)alanine and their derivatives can be obtained from aspartic acid, using hexafluoroacetone as protective group, via 2,2-bis(trifluoromethyl)-4-(3-bromo-2-oxopropyl)-1,3-oxazolidin-5-one (3) in a Hantzsch synthesis.
Burger,Gold,Neuhauser,Rudolph,Hoss
p. 1145 - 1150
(2007/10/02)
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